Anemia of chronic disease
Anemic syndrome is very widespread among the population. Among the pathogenetic variants, anemia of chronic diseases ranks second among various pathogenetic processes, such as prolonged inflammatory processes. This type of anemia occurs in 27% of cases among other anemias, but it should be noted tha...
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| Format: | Article |
| Language: | Russian |
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Open Systems Publication
2021-07-01
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| Series: | Лечащий Врач |
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| Online Access: | https://journal.lvrach.ru/jour/article/view/724 |
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| author | V. Yu. Pavlova M. A. Smolkov |
| author_facet | V. Yu. Pavlova M. A. Smolkov |
| author_sort | V. Yu. Pavlova |
| collection | DOAJ |
| description | Anemic syndrome is very widespread among the population. Among the pathogenetic variants, anemia of chronic diseases ranks second among various pathogenetic processes, such as prolonged inflammatory processes. This type of anemia occurs in 27% of cases among other anemias, but it should be noted that the incidence of this anemia in some chronic diseases can reach 100%. The article provides basic information about the leading links in the pathogenesis and treatment of anemia of chronic diseases. The pathogenesis is based on a violation of iron metabolism: the exchange of hepcidin, ferroportin, factors that stimulate the production of hepcidin, inflammatory cytokines. To diagnose this type of anemia, it is necessary to carefully collect anamnesis and search for a long-term chronic illness, assess the state of iron metabolism and the level of transferrin, and it is also necessary to differentiate this type of anemia from iron deficiency. The difference between anemia of chronic disease and iron deficiency is that the latter is characterized by an absolute lack of iron, and it is inaccessible to young erythroid precursors. A significant factor is the determination of the type of iron deficiency after the diagnosis of anemia of chronic disease. The basis of the therapeutic approach to the treatment of anemia of chronic disease is the treatment of the underlying disease. In the case when this is not possible, it is necessary to compensate for the anemia by other methods. Modern medicine offers 4 rational approaches to the treatment of anemia of chronic disease: replacement therapy with blood components; ferrotherapy; the use of erythropoiesis stimulants; targeted cytokine therapy. |
| format | Article |
| id | doaj-art-e1bb3aa4c9804f3795a2a49595cf148d |
| institution | Kabale University |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2021-07-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-e1bb3aa4c9804f3795a2a49595cf148d2025-08-20T03:57:51ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812021-07-0103515510.51793/OS.2021.24.3.010723Anemia of chronic diseaseV. Yu. Pavlova0M. A. Smolkov1Kemerovo State Medical University of Ministry of Health of RussiaKemerovo State Medical University of Ministry of Health of RussiaAnemic syndrome is very widespread among the population. Among the pathogenetic variants, anemia of chronic diseases ranks second among various pathogenetic processes, such as prolonged inflammatory processes. This type of anemia occurs in 27% of cases among other anemias, but it should be noted that the incidence of this anemia in some chronic diseases can reach 100%. The article provides basic information about the leading links in the pathogenesis and treatment of anemia of chronic diseases. The pathogenesis is based on a violation of iron metabolism: the exchange of hepcidin, ferroportin, factors that stimulate the production of hepcidin, inflammatory cytokines. To diagnose this type of anemia, it is necessary to carefully collect anamnesis and search for a long-term chronic illness, assess the state of iron metabolism and the level of transferrin, and it is also necessary to differentiate this type of anemia from iron deficiency. The difference between anemia of chronic disease and iron deficiency is that the latter is characterized by an absolute lack of iron, and it is inaccessible to young erythroid precursors. A significant factor is the determination of the type of iron deficiency after the diagnosis of anemia of chronic disease. The basis of the therapeutic approach to the treatment of anemia of chronic disease is the treatment of the underlying disease. In the case when this is not possible, it is necessary to compensate for the anemia by other methods. Modern medicine offers 4 rational approaches to the treatment of anemia of chronic disease: replacement therapy with blood components; ferrotherapy; the use of erythropoiesis stimulants; targeted cytokine therapy.https://journal.lvrach.ru/jour/article/view/724anemiachronic diseasesanemia of chronic diseases pathogenesischronic kidney diseaserheumatoid arthritisoncology |
| spellingShingle | V. Yu. Pavlova M. A. Smolkov Anemia of chronic disease Лечащий Врач anemia chronic diseases anemia of chronic diseases pathogenesis chronic kidney disease rheumatoid arthritis oncology |
| title | Anemia of chronic disease |
| title_full | Anemia of chronic disease |
| title_fullStr | Anemia of chronic disease |
| title_full_unstemmed | Anemia of chronic disease |
| title_short | Anemia of chronic disease |
| title_sort | anemia of chronic disease |
| topic | anemia chronic diseases anemia of chronic diseases pathogenesis chronic kidney disease rheumatoid arthritis oncology |
| url | https://journal.lvrach.ru/jour/article/view/724 |
| work_keys_str_mv | AT vyupavlova anemiaofchronicdisease AT masmolkov anemiaofchronicdisease |