Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis
Previous studies that explored the prognostic and clinical value of the systemic immune-inflammation index (SII) in biliary tract cancer (BTC) had inconsistent results. We conducted this meta-analysis to evaluate the prognostic and clinicopathological role of the SII in biliary tract cancer. Combine...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/6988489 |
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| author | Xiulan Peng Xia Wang Li Hua Rui Yang |
| author_facet | Xiulan Peng Xia Wang Li Hua Rui Yang |
| author_sort | Xiulan Peng |
| collection | DOAJ |
| description | Previous studies that explored the prognostic and clinical value of the systemic immune-inflammation index (SII) in biliary tract cancer (BTC) had inconsistent results. We conducted this meta-analysis to evaluate the prognostic and clinicopathological role of the SII in biliary tract cancer. Combined analysis demonstrated that high SII levels had worse overall survival (HR=1.92, 95% CI: 1.66–2.21, p<0.001) than those with low SII levels. And an elevated SII was associated with lymph node metastasis (OR=1.44, 95% CI=1.18‐1.76; p<0.001), TNM stage (OR=1.49, 95% CI=1.05‐2.13; p=0.028), and vascular invasion (OR=1.49, 95% CI=1.05‐2.13; p=0.028). Conversely, no significant association between a high SII and sex or tumor differentiation was found. Our findings demonstrate that high SII levels were correlated with unfavorable survival outcomes among patients with BTC and that they were also correlated with some higher malignancy features of BTC. |
| format | Article |
| id | doaj-art-e1ba916bb94c4d71a3374413931df6f3 |
| institution | DOAJ |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e1ba916bb94c4d71a3374413931df6f32025-08-20T03:20:59ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/6988489Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-AnalysisXiulan Peng0Xia Wang1Li Hua2Rui Yang3Department of OncologyDepartment of PharmacyDepartment of General MedicineDepartment of Vascular SurgeryPrevious studies that explored the prognostic and clinical value of the systemic immune-inflammation index (SII) in biliary tract cancer (BTC) had inconsistent results. We conducted this meta-analysis to evaluate the prognostic and clinicopathological role of the SII in biliary tract cancer. Combined analysis demonstrated that high SII levels had worse overall survival (HR=1.92, 95% CI: 1.66–2.21, p<0.001) than those with low SII levels. And an elevated SII was associated with lymph node metastasis (OR=1.44, 95% CI=1.18‐1.76; p<0.001), TNM stage (OR=1.49, 95% CI=1.05‐2.13; p=0.028), and vascular invasion (OR=1.49, 95% CI=1.05‐2.13; p=0.028). Conversely, no significant association between a high SII and sex or tumor differentiation was found. Our findings demonstrate that high SII levels were correlated with unfavorable survival outcomes among patients with BTC and that they were also correlated with some higher malignancy features of BTC.http://dx.doi.org/10.1155/2022/6988489 |
| spellingShingle | Xiulan Peng Xia Wang Li Hua Rui Yang Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis Journal of Immunology Research |
| title | Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis |
| title_full | Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis |
| title_fullStr | Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis |
| title_full_unstemmed | Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis |
| title_short | Prognostic and Clinical Value of the Systemic Immune-Inflammation Index in Biliary Tract Cancer: A Meta-Analysis |
| title_sort | prognostic and clinical value of the systemic immune inflammation index in biliary tract cancer a meta analysis |
| url | http://dx.doi.org/10.1155/2022/6988489 |
| work_keys_str_mv | AT xiulanpeng prognosticandclinicalvalueofthesystemicimmuneinflammationindexinbiliarytractcancerametaanalysis AT xiawang prognosticandclinicalvalueofthesystemicimmuneinflammationindexinbiliarytractcancerametaanalysis AT lihua prognosticandclinicalvalueofthesystemicimmuneinflammationindexinbiliarytractcancerametaanalysis AT ruiyang prognosticandclinicalvalueofthesystemicimmuneinflammationindexinbiliarytractcancerametaanalysis |