Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films
The hydrolysis and condensation reactions involved in synthesis of ureasil-polyether films influence the film formation time and the number of chemical groups able to form hydrogen bonds, responsible for the bioadhesion, with the biological substrate. The objective of this work was to study the infl...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2015/727324 |
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| _version_ | 1832560071576387584 |
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| author | João Augusto Oshiro Junior Flávia Chiva Carvalho Christiane Pienna Soares Marlus Chorilli Leila Aparecida Chiavacci |
| author_facet | João Augusto Oshiro Junior Flávia Chiva Carvalho Christiane Pienna Soares Marlus Chorilli Leila Aparecida Chiavacci |
| author_sort | João Augusto Oshiro Junior |
| collection | DOAJ |
| description | The hydrolysis and condensation reactions involved in synthesis of ureasil-polyether films influence the film formation time and the number of chemical groups able to form hydrogen bonds, responsible for the bioadhesion, with the biological substrate. The objective of this work was to study the influence of the use of an acid catalyst (hydrochloric acid) and a basic catalyst (ammonium fluoride) in the hydrolysis and condensation reactions on the time formation and bioadhesion of ureasil-polyether films. The toxicity of the films was evaluated. The MTT assay has shown cell viability of human skin keratinocytes higher than 70% of all analyzed materials suggesting low cytotoxicity. The bioadhesion of the films is strongly dependent on the viscosity and hydrophilic/hydrophobic balance of the polyether chains used to synthetize the hybrid molecules. The use of acid catalyst promotes the formation of less viscous films with higher bioadhesion. The hybrids formed by more hydrophilic PEO chains are more bioadherent, since they can interact more efficiently with the water present in the stratum corneum increasing the bioadhesion. Due to their low toxicity and high bioadhesion, the ureasil-PEO films obtained by using HCl as catalyst agent are good candidates for application to the skin as bioadhesive films. |
| format | Article |
| id | doaj-art-e1b87bbdbddf46319498c40111595cd3 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-e1b87bbdbddf46319498c40111595cd32025-02-03T01:28:35ZengWileyInternational Journal of Polymer Science1687-94221687-94302015-01-01201510.1155/2015/727324727324Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid FilmsJoão Augusto Oshiro Junior0Flávia Chiva Carvalho1Christiane Pienna Soares2Marlus Chorilli3Leila Aparecida Chiavacci4Pharmaceutical Sciences School of São Paulo State University (UNESP), Araraquara-Jaú Interstate Highway, Km 1, 14801-902 Araraquara, SP, BrazilPharmaceutical Sciences School of São Paulo State University (UNESP), Araraquara-Jaú Interstate Highway, Km 1, 14801-902 Araraquara, SP, BrazilPharmaceutical Sciences School of São Paulo State University (UNESP), Araraquara-Jaú Interstate Highway, Km 1, 14801-902 Araraquara, SP, BrazilPharmaceutical Sciences School of São Paulo State University (UNESP), Araraquara-Jaú Interstate Highway, Km 1, 14801-902 Araraquara, SP, BrazilPharmaceutical Sciences School of São Paulo State University (UNESP), Araraquara-Jaú Interstate Highway, Km 1, 14801-902 Araraquara, SP, BrazilThe hydrolysis and condensation reactions involved in synthesis of ureasil-polyether films influence the film formation time and the number of chemical groups able to form hydrogen bonds, responsible for the bioadhesion, with the biological substrate. The objective of this work was to study the influence of the use of an acid catalyst (hydrochloric acid) and a basic catalyst (ammonium fluoride) in the hydrolysis and condensation reactions on the time formation and bioadhesion of ureasil-polyether films. The toxicity of the films was evaluated. The MTT assay has shown cell viability of human skin keratinocytes higher than 70% of all analyzed materials suggesting low cytotoxicity. The bioadhesion of the films is strongly dependent on the viscosity and hydrophilic/hydrophobic balance of the polyether chains used to synthetize the hybrid molecules. The use of acid catalyst promotes the formation of less viscous films with higher bioadhesion. The hybrids formed by more hydrophilic PEO chains are more bioadherent, since they can interact more efficiently with the water present in the stratum corneum increasing the bioadhesion. Due to their low toxicity and high bioadhesion, the ureasil-PEO films obtained by using HCl as catalyst agent are good candidates for application to the skin as bioadhesive films.http://dx.doi.org/10.1155/2015/727324 |
| spellingShingle | João Augusto Oshiro Junior Flávia Chiva Carvalho Christiane Pienna Soares Marlus Chorilli Leila Aparecida Chiavacci Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films International Journal of Polymer Science |
| title | Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films |
| title_full | Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films |
| title_fullStr | Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films |
| title_full_unstemmed | Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films |
| title_short | Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films |
| title_sort | development of cutaneous bioadhesive ureasil polyether hybrid films |
| url | http://dx.doi.org/10.1155/2015/727324 |
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