Identification and validation of synergistic drug strategies targeting macrophage polarization in triple-negative breast cancer via single-cell transcriptomics and deep learning

Identification and validation of synergistic drug strategies targeting macrophage polarization in triple-negative breast cancer via single-cell transcriptomics and deep learning

Triple-negative breast cancer (TNBC) presents therapeutic challenges due to its immunosuppressive tumor microenvironment (TME) and limited targeted options. Analyzing scRNA-seq data from 24 TNBC patients using integrated transcriptomics, machine-learning, and pseudo-time trajectory mapping, we devel...

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Bibliographic Details
Main Authors: Qi Qi, Wenhao Yang, Liang Li, Yuheng Tang, Yongzhi Chen, Hui Wang, Sun Yingjie, Jialin Shi, Samina Gul, Wenru Tang, Jianyu Pang, Xiaoli Xie
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Translational Oncology
Subjects:
Triple-negative breast cancer
Tumor microenvironment
Macrophage polarization
ZBTB20
Combination therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001883
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