Inositol metabolism as a broad-spectrum antiviral target
Inositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, formation of replication organelles, assembly and release. For...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1620775/full |
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| _version_ | 1849222425176178688 |
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| author | Kunlakanya Jitobaom Kunlakanya Jitobaom Prasert Auewarakul Prasert Auewarakul |
| author_facet | Kunlakanya Jitobaom Kunlakanya Jitobaom Prasert Auewarakul Prasert Auewarakul |
| author_sort | Kunlakanya Jitobaom |
| collection | DOAJ |
| description | Inositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, formation of replication organelles, assembly and release. For these processes, viruses recruit phosphatidylinositol kinases to meet their demand of phosphatidylinositol phosphates. Inhibitors of phosphatidylinositol kinases have been shown to inhibit various viruses. The complexity of various types and isoforms of phosphatidylinositol kinases can be a problem in developing a broad-spectrum antiviral as different viruses use various types and isoforms of the enzyme. Inositol monophosphatase is an enzyme required for both de novo biosynthesis and intracellular recycling of inositol. It can provide a chokepoint to limit the availability of cellular inositol, phosphatidylinositol, and phosphatidylinositol phosphates. It can be a promising target for broad-spectrum antiviral development. |
| format | Article |
| id | doaj-art-e1b0f896981545da9a351b21429276b4 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-e1b0f896981545da9a351b21429276b42025-08-26T05:28:11ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-08-011610.3389/fmicb.2025.16207751620775Inositol metabolism as a broad-spectrum antiviral targetKunlakanya Jitobaom0Kunlakanya Jitobaom1Prasert Auewarakul2Prasert Auewarakul3Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandEmerging Infectious Research Unit, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandEmerging Infectious Research Unit, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandInositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, formation of replication organelles, assembly and release. For these processes, viruses recruit phosphatidylinositol kinases to meet their demand of phosphatidylinositol phosphates. Inhibitors of phosphatidylinositol kinases have been shown to inhibit various viruses. The complexity of various types and isoforms of phosphatidylinositol kinases can be a problem in developing a broad-spectrum antiviral as different viruses use various types and isoforms of the enzyme. Inositol monophosphatase is an enzyme required for both de novo biosynthesis and intracellular recycling of inositol. It can provide a chokepoint to limit the availability of cellular inositol, phosphatidylinositol, and phosphatidylinositol phosphates. It can be a promising target for broad-spectrum antiviral development.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1620775/fullphosphatidylinositolinositol monophosphatasephosphatidylinositol kinasemyo-inositol metabolismbroad-spectrum antiviralhost-virus interaction |
| spellingShingle | Kunlakanya Jitobaom Kunlakanya Jitobaom Prasert Auewarakul Prasert Auewarakul Inositol metabolism as a broad-spectrum antiviral target Frontiers in Microbiology phosphatidylinositol inositol monophosphatase phosphatidylinositol kinase myo-inositol metabolism broad-spectrum antiviral host-virus interaction |
| title | Inositol metabolism as a broad-spectrum antiviral target |
| title_full | Inositol metabolism as a broad-spectrum antiviral target |
| title_fullStr | Inositol metabolism as a broad-spectrum antiviral target |
| title_full_unstemmed | Inositol metabolism as a broad-spectrum antiviral target |
| title_short | Inositol metabolism as a broad-spectrum antiviral target |
| title_sort | inositol metabolism as a broad spectrum antiviral target |
| topic | phosphatidylinositol inositol monophosphatase phosphatidylinositol kinase myo-inositol metabolism broad-spectrum antiviral host-virus interaction |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1620775/full |
| work_keys_str_mv | AT kunlakanyajitobaom inositolmetabolismasabroadspectrumantiviraltarget AT kunlakanyajitobaom inositolmetabolismasabroadspectrumantiviraltarget AT prasertauewarakul inositolmetabolismasabroadspectrumantiviraltarget AT prasertauewarakul inositolmetabolismasabroadspectrumantiviraltarget |