Carnitine Deficiency after Long-Term Continuous Renal Replacement Therapy

A 60-year-old man was admitted in the intensive care unit (ICU) for a rapidly progressive respiratory failure due to SARS-CoV-2 infection. He developed numerous complications including acute kidney injury (AKI) requiring prolonged continuous renal replacement therapy (CRRT). Enteral feeding was init...

Full description

Saved in:
Bibliographic Details
Main Authors: Caroline Van de Wyngaert, Joseph P. Dewulf, Christine Collienne, Pierre-François Laterre, Philippe Hantson
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Case Reports in Critical Care
Online Access:http://dx.doi.org/10.1155/2022/4142539
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850165822280957952
author Caroline Van de Wyngaert
Joseph P. Dewulf
Christine Collienne
Pierre-François Laterre
Philippe Hantson
author_facet Caroline Van de Wyngaert
Joseph P. Dewulf
Christine Collienne
Pierre-François Laterre
Philippe Hantson
author_sort Caroline Van de Wyngaert
collection DOAJ
description A 60-year-old man was admitted in the intensive care unit (ICU) for a rapidly progressive respiratory failure due to SARS-CoV-2 infection. He developed numerous complications including acute kidney injury (AKI) requiring prolonged continuous renal replacement therapy (CRRT). Enteral feeding was initiated on day 8. Despite nutritional management, there was a remarkable amyotrophy and weight loss. On day 85 in the ICU, the patient became progressively unresponsive. An extensive metabolic workup was performed, and blood results showed hyperammoniemia and hypertriglyceridemia. Plasma free carnitine level was low, as was also copper. After carnitine supplementation, the neurological condition rapidly improved, and metabolic perturbations regressed. Prolonged CRRT may be complicated by clinically significant deficiency in micronutrients and trace elements.
format Article
id doaj-art-e1abc69fbade41309567d847ba8d23bf
institution OA Journals
issn 2090-6439
language English
publishDate 2022-01-01
publisher Wiley
record_format Article
series Case Reports in Critical Care
spelling doaj-art-e1abc69fbade41309567d847ba8d23bf2025-08-20T02:21:38ZengWileyCase Reports in Critical Care2090-64392022-01-01202210.1155/2022/4142539Carnitine Deficiency after Long-Term Continuous Renal Replacement TherapyCaroline Van de Wyngaert0Joseph P. Dewulf1Christine Collienne2Pierre-François Laterre3Philippe Hantson4Department of Intensive CareDepartment of Clinical ChemistryDepartment of Intensive CareDepartment of Intensive CareDepartment of Intensive CareA 60-year-old man was admitted in the intensive care unit (ICU) for a rapidly progressive respiratory failure due to SARS-CoV-2 infection. He developed numerous complications including acute kidney injury (AKI) requiring prolonged continuous renal replacement therapy (CRRT). Enteral feeding was initiated on day 8. Despite nutritional management, there was a remarkable amyotrophy and weight loss. On day 85 in the ICU, the patient became progressively unresponsive. An extensive metabolic workup was performed, and blood results showed hyperammoniemia and hypertriglyceridemia. Plasma free carnitine level was low, as was also copper. After carnitine supplementation, the neurological condition rapidly improved, and metabolic perturbations regressed. Prolonged CRRT may be complicated by clinically significant deficiency in micronutrients and trace elements.http://dx.doi.org/10.1155/2022/4142539
spellingShingle Caroline Van de Wyngaert
Joseph P. Dewulf
Christine Collienne
Pierre-François Laterre
Philippe Hantson
Carnitine Deficiency after Long-Term Continuous Renal Replacement Therapy
Case Reports in Critical Care
title Carnitine Deficiency after Long-Term Continuous Renal Replacement Therapy
title_full Carnitine Deficiency after Long-Term Continuous Renal Replacement Therapy
title_fullStr Carnitine Deficiency after Long-Term Continuous Renal Replacement Therapy
title_full_unstemmed Carnitine Deficiency after Long-Term Continuous Renal Replacement Therapy
title_short Carnitine Deficiency after Long-Term Continuous Renal Replacement Therapy
title_sort carnitine deficiency after long term continuous renal replacement therapy
url http://dx.doi.org/10.1155/2022/4142539
work_keys_str_mv AT carolinevandewyngaert carnitinedeficiencyafterlongtermcontinuousrenalreplacementtherapy
AT josephpdewulf carnitinedeficiencyafterlongtermcontinuousrenalreplacementtherapy
AT christinecollienne carnitinedeficiencyafterlongtermcontinuousrenalreplacementtherapy
AT pierrefrancoislaterre carnitinedeficiencyafterlongtermcontinuousrenalreplacementtherapy
AT philippehantson carnitinedeficiencyafterlongtermcontinuousrenalreplacementtherapy