Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery

Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery

Heavy chain-only antibodies have found many applications where conventional heavy-light heterodimeric antibodies are not favorable. Heavy chain-only antibodies with their single antigen-binding domain offer the advantage of a smaller size and higher stability relative to conventional antibodies, and...

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Bibliographic Details
Main Authors: Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Heavy chain-only
sdab
single-domain antibody
transgenic chicken
VHH
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2435476
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