Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study
IntroductionThe association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.MethodsThis was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analys...
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Frontiers Media S.A.
2024-12-01
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| author | Yunxia Feng Yuan Li Yuan Li Shuo Chen Na Hu Dan Liao |
| author_facet | Yunxia Feng Yuan Li Yuan Li Shuo Chen Na Hu Dan Liao |
| author_sort | Yunxia Feng |
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| description | IntroductionThe association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.MethodsThis was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analysis. The primary outcome was all-cause mortality. Person correlation analysis and Cox regression models were used to assess the relation between serum VA levels and all-cause mortality among individuals with CKD.ResultsThere were 689 participants included in this study. The serum VA level was 2.45 ± 1.06 μmol/L. The overall mortality was 43.69%. The participants in the nonsurvival group had higher serum VA levels than those in the survival group (2.18 ± 0.82 vs. 2.78 ± 1.24 μmol/L, p < 0.01). Serum VA concentrations were positively correlated with serum creatinine levels (r = 0.56, p < 0.01) and urea nitrogen (r = 0.58, p < 0.01) but negatively correlated with eGFR (r = −0.56, p < 0.01). The serum VA level was independently related to all-cause mortality (hazard ratio (HR) = 1.15, [95% CI: 1.01–1.31], p = 0.03). The Kaplan–Meier survival analysis suggested that the survival probability was lower in participants with serum VA levels exceeding 2.09 μmol/L than in participants with serum VA levels below 2.09 μmol/L (p < 0.0001).ConclusionA high serum VA was independently related to all-cause mortality in CKD patients. VA requirements for patients with CKD is worth studies in the future. |
| format | Article |
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| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-e1aada401b80428687c61cc532c307dc2025-08-20T02:30:23ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-12-011110.3389/fnut.2024.14698441469844Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort studyYunxia Feng0Yuan Li1Yuan Li2Shuo Chen3Na Hu4Dan Liao5Department of Nephrology, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University, College of Anesthesiology, Zunyi Medical University, Zunyi, ChinaDepartment of Anesthesiology, Mianyang Hospital of Traditional Chinese Medicine, Mianyang, ChinaDepartment of Critical Care Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Nephrology, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Nephrology, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaIntroductionThe association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.MethodsThis was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analysis. The primary outcome was all-cause mortality. Person correlation analysis and Cox regression models were used to assess the relation between serum VA levels and all-cause mortality among individuals with CKD.ResultsThere were 689 participants included in this study. The serum VA level was 2.45 ± 1.06 μmol/L. The overall mortality was 43.69%. The participants in the nonsurvival group had higher serum VA levels than those in the survival group (2.18 ± 0.82 vs. 2.78 ± 1.24 μmol/L, p < 0.01). Serum VA concentrations were positively correlated with serum creatinine levels (r = 0.56, p < 0.01) and urea nitrogen (r = 0.58, p < 0.01) but negatively correlated with eGFR (r = −0.56, p < 0.01). The serum VA level was independently related to all-cause mortality (hazard ratio (HR) = 1.15, [95% CI: 1.01–1.31], p = 0.03). The Kaplan–Meier survival analysis suggested that the survival probability was lower in participants with serum VA levels exceeding 2.09 μmol/L than in participants with serum VA levels below 2.09 μmol/L (p < 0.0001).ConclusionA high serum VA was independently related to all-cause mortality in CKD patients. VA requirements for patients with CKD is worth studies in the future.https://www.frontiersin.org/articles/10.3389/fnut.2024.1469844/fullchronic kidney diseasevitamin Aall-cause mortalityNHANSEcohort study |
| spellingShingle | Yunxia Feng Yuan Li Yuan Li Shuo Chen Na Hu Dan Liao Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study Frontiers in Nutrition chronic kidney disease vitamin A all-cause mortality NHANSE cohort study |
| title | Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study |
| title_full | Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study |
| title_fullStr | Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study |
| title_full_unstemmed | Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study |
| title_short | Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study |
| title_sort | vitamin a is associated with all cause mortality in patients with chronic kidney disease a population based cohort study |
| topic | chronic kidney disease vitamin A all-cause mortality NHANSE cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1469844/full |
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