Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study

Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study

IntroductionThe association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.MethodsThis was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analys...

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Bibliographic Details
Main Authors: Yunxia Feng, Yuan Li, Shuo Chen, Na Hu, Dan Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Nutrition
Subjects:
chronic kidney disease
vitamin A
all-cause mortality
NHANSE
cohort study
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2024.1469844/full
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Summary:IntroductionThe association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.MethodsThis was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analysis. The primary outcome was all-cause mortality. Person correlation analysis and Cox regression models were used to assess the relation between serum VA levels and all-cause mortality among individuals with CKD.ResultsThere were 689 participants included in this study. The serum VA level was 2.45 ± 1.06 μmol/L. The overall mortality was 43.69%. The participants in the nonsurvival group had higher serum VA levels than those in the survival group (2.18 ± 0.82 vs. 2.78 ± 1.24 μmol/L, p < 0.01). Serum VA concentrations were positively correlated with serum creatinine levels (r = 0.56, p < 0.01) and urea nitrogen (r = 0.58, p < 0.01) but negatively correlated with eGFR (r = −0.56, p < 0.01). The serum VA level was independently related to all-cause mortality (hazard ratio (HR) = 1.15, [95% CI: 1.01–1.31], p = 0.03). The Kaplan–Meier survival analysis suggested that the survival probability was lower in participants with serum VA levels exceeding 2.09 μmol/L than in participants with serum VA levels below 2.09 μmol/L (p < 0.0001).ConclusionA high serum VA was independently related to all-cause mortality in CKD patients. VA requirements for patients with CKD is worth studies in the future.
ISSN:2296-861X

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