A complex phylogeny of lineage plasticity in metastatic castration resistant prostate cancer

A complex phylogeny of lineage plasticity in metastatic castration resistant prostate cancer

Abstract Aggressive variant and androgen receptor (AR)-independent castration resistant prostate cancers (CRPC) represent the most significant diagnostic and therapeutic challenges in prostate cancer. This study examined a case of simultaneous progression of both adenocarcinoma and squamous tumors f...

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Main Authors: Jones T. Nauseef, Timothy R. Chu, William F. Hooper, Alicia Alonso, Ali Oku, Heather Geiger, Zoe R. Goldstein, Minita Shah, Michael Sigouros, Jyothi Manohar, Zoe Steinsnyder, Lara Winterkorn, Brian D. Robinson, Andrea Sboner, Himisha Beltran, Olivier Elemento, Iman Hajirasouliha, Marcin Imielinski, David M. Nanus, Scott T. Tagawa, Nicolas Robine, Juan Miguel Mosquera
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00854-4
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