Clinical features of fatigue in amyotrophic lateral sclerosis
Background. Fatigue (athenia) is widely spread among patients with neurological disorders. It substantially reduces patients’ quality of life. Its clinical features and mechanisms of the development have not been studies sufficiently.Aim. To analyze clinical features of fatigue in patients with amyo...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2025-04-01
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| Series: | Нервно-мышечные болезни |
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| Online Access: | https://nmb.abvpress.ru/jour/article/view/644 |
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| author | E. V. Pervushina M. A. Kutlubaev |
| author_facet | E. V. Pervushina M. A. Kutlubaev |
| author_sort | E. V. Pervushina |
| collection | DOAJ |
| description | Background. Fatigue (athenia) is widely spread among patients with neurological disorders. It substantially reduces patients’ quality of life. Its clinical features and mechanisms of the development have not been studies sufficiently.Aim. To analyze clinical features of fatigue in patients with amyotrophic lateral sclerosis.Materials and methods. Forty two patients with amyotrophic lateral sclerosis were recruited to the study. Fatigue was assessed using the Multidimensional Fatigue Inventory (MFI-20). The independent predictors of the severity of fatigue were calculated using linear regression analysis.Results. Fatigue was detected in 27 (64 %) patients. The most common type of fatigue was reduced activity, the least common – general fatigue. Severity of depression and motor neurological deficit were independent predictors of fatigue according to general MFI-20 score.Conclusion. Fatigue in amyotrophic lateral sclerosis is wide spread phenomenon. Its clinical features include both physical and mental components. |
| format | Article |
| id | doaj-art-e1a78bec1395455098e95081947c01fe |
| institution | Kabale University |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| publishDate | 2025-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Нервно-мышечные болезни |
| spelling | doaj-art-e1a78bec1395455098e95081947c01fe2025-08-20T03:38:16ZrusABV-pressНервно-мышечные болезни2222-87212413-04432025-04-01151101710.17650/2222-8721-2025-15-1-10-17404Clinical features of fatigue in amyotrophic lateral sclerosisE. V. Pervushina0M. A. Kutlubaev1Bashkir State Medical University, Ministry of Health of RussiaBashkir State Medical University, Ministry of Health of RussiaBackground. Fatigue (athenia) is widely spread among patients with neurological disorders. It substantially reduces patients’ quality of life. Its clinical features and mechanisms of the development have not been studies sufficiently.Aim. To analyze clinical features of fatigue in patients with amyotrophic lateral sclerosis.Materials and methods. Forty two patients with amyotrophic lateral sclerosis were recruited to the study. Fatigue was assessed using the Multidimensional Fatigue Inventory (MFI-20). The independent predictors of the severity of fatigue were calculated using linear regression analysis.Results. Fatigue was detected in 27 (64 %) patients. The most common type of fatigue was reduced activity, the least common – general fatigue. Severity of depression and motor neurological deficit were independent predictors of fatigue according to general MFI-20 score.Conclusion. Fatigue in amyotrophic lateral sclerosis is wide spread phenomenon. Its clinical features include both physical and mental components.https://nmb.abvpress.ru/jour/article/view/644amyotrophic lateral sclerosisfatiguemotor neuron diseasedepression |
| spellingShingle | E. V. Pervushina M. A. Kutlubaev Clinical features of fatigue in amyotrophic lateral sclerosis Нервно-мышечные болезни amyotrophic lateral sclerosis fatigue motor neuron disease depression |
| title | Clinical features of fatigue in amyotrophic lateral sclerosis |
| title_full | Clinical features of fatigue in amyotrophic lateral sclerosis |
| title_fullStr | Clinical features of fatigue in amyotrophic lateral sclerosis |
| title_full_unstemmed | Clinical features of fatigue in amyotrophic lateral sclerosis |
| title_short | Clinical features of fatigue in amyotrophic lateral sclerosis |
| title_sort | clinical features of fatigue in amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis fatigue motor neuron disease depression |
| url | https://nmb.abvpress.ru/jour/article/view/644 |
| work_keys_str_mv | AT evpervushina clinicalfeaturesoffatigueinamyotrophiclateralsclerosis AT makutlubaev clinicalfeaturesoffatigueinamyotrophiclateralsclerosis |