WS<sub>2</sub>/Si<sub>3</sub>N<sub>4</sub>-Based Biosensor for Low-Concentration Coronavirus Detection
This study presents the optimization of two SPR biosensors, Sys<sub>3</sub> and Sys<sub>5</sub>, for SARS-CoV-2 detection at concentrations of 0.01–100 nM. Sys<sub>3</sub>, with a 55 nm silver layer, a 13 nm silicon nitride layer, and a 10 nm ssDNA layer, achieved...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/16/2/128 |
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| Summary: | This study presents the optimization of two SPR biosensors, Sys<sub>3</sub> and Sys<sub>5</sub>, for SARS-CoV-2 detection at concentrations of 0.01–100 nM. Sys<sub>3</sub>, with a 55 nm silver layer, a 13 nm silicon nitride layer, and a 10 nm ssDNA layer, achieved a figure of merit (FoM) of 571.24 RIU<sup>−1</sup>, a signal-to-noise ratio (SNR) of 0.12, and a detection accuracy (DA) of 48.93 × 10<sup>−2</sup>. Sys<sub>5</sub>, incorporating a 50 nm silver layer, a 10 nm silicon nitride layer, a 10 nm ssDNA layer, and a 1.6 nm tungsten disulfide layer (L = 2), demonstrated a higher sensitivity of 305.33 °/RIU and a lower limit of detection (LoD) of 1.65 × 10<sup>−5</sup>. Sys<sub>3</sub> outshined in precision with low attenuation (<1%), while Sys<sub>5</sub> provided enhanced sensitivity and lower detection limits, crucial for early-stage viral detection. These configurations align with the refractive index ranges of clinical SARS-CoV-2 samples, showcasing their diagnostic potential. Future work will focus on experimental validation and integration into point-of-care platforms. |
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| ISSN: | 2072-666X |