Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosis
Purpose: Advancements in ultra-widefield fundus autofluorescence (FAF) and limitations in healthcare delivery have challenged the role of intravenous fluorescein angiography (IVFA) as the “gold standard” for evaluating the retina complicated by asteroid hyalosis (AH). The objective was to compare ul...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | AJO International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S295025352500036X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849744341997715456 |
|---|---|
| author | William J. Collins Cory A. Christensen Mark P. Breazzano |
| author_facet | William J. Collins Cory A. Christensen Mark P. Breazzano |
| author_sort | William J. Collins |
| collection | DOAJ |
| description | Purpose: Advancements in ultra-widefield fundus autofluorescence (FAF) and limitations in healthcare delivery have challenged the role of intravenous fluorescein angiography (IVFA) as the “gold standard” for evaluating the retina complicated by asteroid hyalosis (AH). The objective was to compare ultra-widefield retinal imaging methods – both non-invasive (pseudocolor fundus photography [CFP] and FAF) and IVFA modalities – in patients with AH. Design: Retrospective, observational, cross-sectional, single-institution study. Participants: One hundred and thirty patients identified via billing codes. Methods: Same-day, ultra-widefield retinal imaging modality (CFP, FAF, and IVFA) and diagnosis compatible with AH had image quality compared by standardized grading, including sub-analysis with retinal location. Image quality was defined as the degree of retinal image obscuration from asteroids and was independently measured by two researchers. Agreement was calculated based on predetermined definition. Results: Forty-one patients fulfilled criteria. Imaging modality had a statistically significant effect on image quality in patients with AH (F = 69.4, p < 0.001). The region of the retina imaged also had a statistically significant effect (F = 2.9, p = 0.021). Tukey’s honestly significant difference test found that image quality was significantly greater in FAF compared to CFP (p < 0.001), as well as IVFA compared to CFP (p < 0.001). However, there was no significant difference of image quality between FAF and IVFA (p = 0.187). Conclusions: These findings suggest that FAF is comparable in image quality to IVFA when generally assessing the retina with ultra-widefield imaging in patients with AH. Ultra-widefield FAF may serve as a reasonable alternative to IVFA for evaluating patients with these vitreous opacities in the appropriate clinical context. |
| format | Article |
| id | doaj-art-e19a5843d5a5489d9eeb5d7f429d84ba |
| institution | DOAJ |
| issn | 2950-2535 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJO International |
| spelling | doaj-art-e19a5843d5a5489d9eeb5d7f429d84ba2025-08-20T03:19:57ZengElsevierAJO International2950-25352025-07-012210013310.1016/j.ajoint.2025.100133Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosisWilliam J. Collins0Cory A. Christensen1Mark P. Breazzano2SUNY Upstate Medical University, Norton College of Medicine, 766 Irving Ave, Syracuse, NY 13210, United StatesSUNY Upstate Medical University, Department of Ophthalmology & Visual Sciences, 550 Harrison St, Syracuse, NY 13202, United StatesSUNY Upstate Medical University, Department of Ophthalmology & Visual Sciences, 550 Harrison St, Syracuse, NY 13202, United States; Flaum Eye Institute, University of Rochester Medical Center, 210 Crittenden Blvd, Rochester, NY 14642, United States; Corresponding author at: 210 Crittenden Blvd, Rochester, NY 14642, United States.Purpose: Advancements in ultra-widefield fundus autofluorescence (FAF) and limitations in healthcare delivery have challenged the role of intravenous fluorescein angiography (IVFA) as the “gold standard” for evaluating the retina complicated by asteroid hyalosis (AH). The objective was to compare ultra-widefield retinal imaging methods – both non-invasive (pseudocolor fundus photography [CFP] and FAF) and IVFA modalities – in patients with AH. Design: Retrospective, observational, cross-sectional, single-institution study. Participants: One hundred and thirty patients identified via billing codes. Methods: Same-day, ultra-widefield retinal imaging modality (CFP, FAF, and IVFA) and diagnosis compatible with AH had image quality compared by standardized grading, including sub-analysis with retinal location. Image quality was defined as the degree of retinal image obscuration from asteroids and was independently measured by two researchers. Agreement was calculated based on predetermined definition. Results: Forty-one patients fulfilled criteria. Imaging modality had a statistically significant effect on image quality in patients with AH (F = 69.4, p < 0.001). The region of the retina imaged also had a statistically significant effect (F = 2.9, p = 0.021). Tukey’s honestly significant difference test found that image quality was significantly greater in FAF compared to CFP (p < 0.001), as well as IVFA compared to CFP (p < 0.001). However, there was no significant difference of image quality between FAF and IVFA (p = 0.187). Conclusions: These findings suggest that FAF is comparable in image quality to IVFA when generally assessing the retina with ultra-widefield imaging in patients with AH. Ultra-widefield FAF may serve as a reasonable alternative to IVFA for evaluating patients with these vitreous opacities in the appropriate clinical context.http://www.sciencedirect.com/science/article/pii/S295025352500036XAsteroid hyalosis (AH)Pseudocolor fundus photography (CFP)Fundus autofluorescence (FAF)Intravenous fluorescein angiography (IVFA) |
| spellingShingle | William J. Collins Cory A. Christensen Mark P. Breazzano Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosis AJO International Asteroid hyalosis (AH) Pseudocolor fundus photography (CFP) Fundus autofluorescence (FAF) Intravenous fluorescein angiography (IVFA) |
| title | Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosis |
| title_full | Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosis |
| title_fullStr | Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosis |
| title_full_unstemmed | Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosis |
| title_short | Comparison of ultra-widefield retinal imaging modalities in eyes with asteroid hyalosis |
| title_sort | comparison of ultra widefield retinal imaging modalities in eyes with asteroid hyalosis |
| topic | Asteroid hyalosis (AH) Pseudocolor fundus photography (CFP) Fundus autofluorescence (FAF) Intravenous fluorescein angiography (IVFA) |
| url | http://www.sciencedirect.com/science/article/pii/S295025352500036X |
| work_keys_str_mv | AT williamjcollins comparisonofultrawidefieldretinalimagingmodalitiesineyeswithasteroidhyalosis AT coryachristensen comparisonofultrawidefieldretinalimagingmodalitiesineyeswithasteroidhyalosis AT markpbreazzano comparisonofultrawidefieldretinalimagingmodalitiesineyeswithasteroidhyalosis |