Progress of radiomics research on white matter hyperintensity lesions
White matter hyperintensity (WMH) is the core imaging hallmark of cerebral small vessel disease (CSVD). This phenomenon is closely related to nervous system damage, such as cognitive impairment, dementia and increased risk of stroke. However, traditional diagnostic methods have significant limitatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1647724/full |
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| author | Lin Du Lieping Wang Gang Shen Min Zeng Desheng Li Weiguo Li |
| author_facet | Lin Du Lieping Wang Gang Shen Min Zeng Desheng Li Weiguo Li |
| author_sort | Lin Du |
| collection | DOAJ |
| description | White matter hyperintensity (WMH) is the core imaging hallmark of cerebral small vessel disease (CSVD). This phenomenon is closely related to nervous system damage, such as cognitive impairment, dementia and increased risk of stroke. However, traditional diagnostic methods have significant limitations in terms of quantitative assessment, analysis of pathological mechanisms, and clinical decision support, which severely restrict their clinical application. Through high-throughput feature extraction and comprehensive analysis of clinical, laboratory, histological, and genomic data, radiomics in its current form can not only achieve the high-precision identification and staging of WMH but also help to reveal its pathological mechanism, which has shown important value in the diagnosis, prognosis, and evaluation of WMH-related diseases. Against this backdrop, we strictly adhered to the norms of systematic literature reviews, conducting a comprehensive and transparent literature search. We also thoroughly reviewed the data using a predefined strategy and strict inclusion/exclusion criteria (detailed in the text). This article systematically reviews the progress of radiomics research in characterizing the pathological mechanism of WMH and in the early identification, classification and prognostic evaluation of related diseases, aiming to provide a theoretical basis and a technical reference for the early identification of high-risk groups, the optimization of diagnosis and treatment decision-making, and the practice of collaborative patient management. |
| format | Article |
| id | doaj-art-e198f277171d44768624401cdcbe942c |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e198f277171d44768624401cdcbe942c2025-08-26T04:13:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-08-011610.3389/fneur.2025.16477241647724Progress of radiomics research on white matter hyperintensity lesionsLin Du0Lieping Wang1Gang Shen2Min Zeng3Desheng Li4Weiguo Li5Department of Radiology, Chongqing Tongliang District Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Radiology, Chongqing Tongliang District Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Radiology, Chongqing Tongliang District Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Radiology, Chongqing Tongliang District Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Radiology, Chongqing Tongliang District Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Acupuncture and Pain, Chongqing Tongliang District Hospital of Traditional Chinese Medicine, Chongqing, ChinaWhite matter hyperintensity (WMH) is the core imaging hallmark of cerebral small vessel disease (CSVD). This phenomenon is closely related to nervous system damage, such as cognitive impairment, dementia and increased risk of stroke. However, traditional diagnostic methods have significant limitations in terms of quantitative assessment, analysis of pathological mechanisms, and clinical decision support, which severely restrict their clinical application. Through high-throughput feature extraction and comprehensive analysis of clinical, laboratory, histological, and genomic data, radiomics in its current form can not only achieve the high-precision identification and staging of WMH but also help to reveal its pathological mechanism, which has shown important value in the diagnosis, prognosis, and evaluation of WMH-related diseases. Against this backdrop, we strictly adhered to the norms of systematic literature reviews, conducting a comprehensive and transparent literature search. We also thoroughly reviewed the data using a predefined strategy and strict inclusion/exclusion criteria (detailed in the text). This article systematically reviews the progress of radiomics research in characterizing the pathological mechanism of WMH and in the early identification, classification and prognostic evaluation of related diseases, aiming to provide a theoretical basis and a technical reference for the early identification of high-risk groups, the optimization of diagnosis and treatment decision-making, and the practice of collaborative patient management.https://www.frontiersin.org/articles/10.3389/fneur.2025.1647724/fullwhite matter hyperintensity (WMH)cerebral small vessel disease (CSVD)radiomicscognitive impairmentstroke risk |
| spellingShingle | Lin Du Lieping Wang Gang Shen Min Zeng Desheng Li Weiguo Li Progress of radiomics research on white matter hyperintensity lesions Frontiers in Neurology white matter hyperintensity (WMH) cerebral small vessel disease (CSVD) radiomics cognitive impairment stroke risk |
| title | Progress of radiomics research on white matter hyperintensity lesions |
| title_full | Progress of radiomics research on white matter hyperintensity lesions |
| title_fullStr | Progress of radiomics research on white matter hyperintensity lesions |
| title_full_unstemmed | Progress of radiomics research on white matter hyperintensity lesions |
| title_short | Progress of radiomics research on white matter hyperintensity lesions |
| title_sort | progress of radiomics research on white matter hyperintensity lesions |
| topic | white matter hyperintensity (WMH) cerebral small vessel disease (CSVD) radiomics cognitive impairment stroke risk |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1647724/full |
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