Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations
ABSTRACT: Background: Pueraria, a renowned traditional Chinese herb, has been valued for both medicinal and culinary uses. Puerarin, its primary bioactive compound, exhibits a diverse pharmacological profile and has garnered attention for its hepatoprotective properties. This review explores puerar...
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Elsevier
2025-03-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142525000235 |
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| author | Lokeshvar Ravikumar Ramaiyan Velmurugan J Sam Helinto S Yokesh B Divya Harshitha GS Harish Kanna S Mahalakshmi Devaraji |
| author_facet | Lokeshvar Ravikumar Ramaiyan Velmurugan J Sam Helinto S Yokesh B Divya Harshitha GS Harish Kanna S Mahalakshmi Devaraji |
| author_sort | Lokeshvar Ravikumar |
| collection | DOAJ |
| description | ABSTRACT: Background: Pueraria, a renowned traditional Chinese herb, has been valued for both medicinal and culinary uses. Puerarin, its primary bioactive compound, exhibits a diverse pharmacological profile and has garnered attention for its hepatoprotective properties. This review explores puerarin's potential in managing liver diseases, including hepatic malignancy, alcohol-associated liver disease, and metabolic dysfunction-associated steatotic liver disease. Methods: An extensive literature review was conducted, analyzing studies that examine puerarin's effects on liver disease pathways. Emphasis was placed on its mechanisms involving lipid metabolism regulation, oxidative stress reduction, autophagy induction, and inflammation modulation. The review also evaluates novel drug delivery techniques designed to enhance puerarin's bioavailability, given its limited solubility. Results: Puerarin demonstrates therapeutic efficacy across various liver diseases by targeting key biochemical pathways. Studies show it effectively modulates lipid levels, reduces oxidative stress, induces autophagy, and decreases inflammation. Recent advances in drug delivery have significantly improved puerarin's bioavailability, enhancing its clinical application potential. Discussion and Conclusion: Puerarin holds promise as a safe, low-toxicity treatment for liver diseases, backed by favourable pharmacological activity and clinical trial data. Its hepatoprotective actions are further strengthened through innovative drug delivery methods, highlighting puerarin's viability in therapeutic applications. Continued research is recommended to further understand its mechanisms and optimize delivery strategies. Puerarin's unique pharmacological profile positions it as a potential therapeutic agent for liver disease management. |
| format | Article |
| id | doaj-art-e1964fbb8f9943c2bfde692853b3cca8 |
| institution | DOAJ |
| issn | 2667-1425 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj-art-e1964fbb8f9943c2bfde692853b3cca82025-08-20T02:55:48ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252025-03-011410059410.1016/j.prmcm.2025.100594Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovationsLokeshvar Ravikumar0Ramaiyan Velmurugan1J Sam Helinto2S Yokesh3B Divya4Harshitha GS5Harish Kanna S6Mahalakshmi Devaraji7Department of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, 602105, IndiaDepartment of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, 602105, IndiaDepartment of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, 602105, IndiaDepartment of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, 602105, IndiaDepartment of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, IndiaDepartment of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, IndiaDepartment of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, IndiaDepartment of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, India; Corresponding author.ABSTRACT: Background: Pueraria, a renowned traditional Chinese herb, has been valued for both medicinal and culinary uses. Puerarin, its primary bioactive compound, exhibits a diverse pharmacological profile and has garnered attention for its hepatoprotective properties. This review explores puerarin's potential in managing liver diseases, including hepatic malignancy, alcohol-associated liver disease, and metabolic dysfunction-associated steatotic liver disease. Methods: An extensive literature review was conducted, analyzing studies that examine puerarin's effects on liver disease pathways. Emphasis was placed on its mechanisms involving lipid metabolism regulation, oxidative stress reduction, autophagy induction, and inflammation modulation. The review also evaluates novel drug delivery techniques designed to enhance puerarin's bioavailability, given its limited solubility. Results: Puerarin demonstrates therapeutic efficacy across various liver diseases by targeting key biochemical pathways. Studies show it effectively modulates lipid levels, reduces oxidative stress, induces autophagy, and decreases inflammation. Recent advances in drug delivery have significantly improved puerarin's bioavailability, enhancing its clinical application potential. Discussion and Conclusion: Puerarin holds promise as a safe, low-toxicity treatment for liver diseases, backed by favourable pharmacological activity and clinical trial data. Its hepatoprotective actions are further strengthened through innovative drug delivery methods, highlighting puerarin's viability in therapeutic applications. Continued research is recommended to further understand its mechanisms and optimize delivery strategies. Puerarin's unique pharmacological profile positions it as a potential therapeutic agent for liver disease management.http://www.sciencedirect.com/science/article/pii/S2667142525000235PuerarinChinese herbal medicinePharmacological effectsLiver disease |
| spellingShingle | Lokeshvar Ravikumar Ramaiyan Velmurugan J Sam Helinto S Yokesh B Divya Harshitha GS Harish Kanna S Mahalakshmi Devaraji Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations Pharmacological Research - Modern Chinese Medicine Puerarin Chinese herbal medicine Pharmacological effects Liver disease |
| title | Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations |
| title_full | Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations |
| title_fullStr | Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations |
| title_full_unstemmed | Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations |
| title_short | Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations |
| title_sort | therapeutic potential and mechanisms of puerarin in liver disease a comprehensive review of pharmacological effects and drug delivery innovations |
| topic | Puerarin Chinese herbal medicine Pharmacological effects Liver disease |
| url | http://www.sciencedirect.com/science/article/pii/S2667142525000235 |
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