Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility
Infertility has become one of the most common chronic diseases among reproductive- aged individuals, and male factors account for about 50 %. Zinc is a trace element that is essential for sperm quality and male reproductive system. Although several current studies with small sample sizes have invest...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-10-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324009655 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850264297533341696 |
|---|---|
| author | Yu Chen Xiaoyu Wang Jing Zhou Ganlin Wang Tingting Gao Hai Wei Yurui Che Tianfu Li Zhenglin Zhang Shuxian Wang Lingmin Hu Renjie Lu |
| author_facet | Yu Chen Xiaoyu Wang Jing Zhou Ganlin Wang Tingting Gao Hai Wei Yurui Che Tianfu Li Zhenglin Zhang Shuxian Wang Lingmin Hu Renjie Lu |
| author_sort | Yu Chen |
| collection | DOAJ |
| description | Infertility has become one of the most common chronic diseases among reproductive- aged individuals, and male factors account for about 50 %. Zinc is a trace element that is essential for sperm quality and male reproductive system. Although several current studies with small sample sizes have investigated this relationship, the conclusions have been still controversial. Here, using a large population sample involved 25,915 participants from Changzhou Maternity and Child Health Care Hospital, we revealed an inverted “U”-shaped trend between seminal plasma zinc concentrations and sperm motility PR/PR + NP (PR, progressive motility; NP, non-progressive motility). The results showed that the highest values of sperm PR/PR + NP observed in the group with intermediate concentrations of zinc (Group 2, 0.25–2.11 mmol/L). The mean values were 43.17 ± 19.03 % and 56.64 ± 20.28 %, respectively. And the lowest values came out in the highest zinc levels group (Group 4, > 3.04 mmol/L). In vitro cell experiments also showed that zinc caused dose-dependent cytotoxicity for GC-2 cells at a threshold value. Furthermore, RNA-seq analysis demonstrated that high concentrations of zinc exerted toxic effects on GC-2 cells through immune injury. Taken together, our findings suggested that moderate amounts of zinc are crucial for human reproduction and excessive concentrations may have adverse effects on male fertility. |
| format | Article |
| id | doaj-art-e19498b5c21c47919f3b4a2f371f881a |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e19498b5c21c47919f3b4a2f371f881a2025-08-20T01:54:44ZengElsevierEcotoxicology and Environmental Safety0147-65132024-10-0128411688910.1016/j.ecoenv.2024.116889Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motilityYu Chen0Xiaoyu Wang1Jing Zhou2Ganlin Wang3Tingting Gao4Hai Wei5Yurui Che6Tianfu Li7Zhenglin Zhang8Shuxian Wang9Lingmin Hu10Renjie Lu11Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Third People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Third People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, ChinaChangzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, China; Corresponding authors.Changzhou Third People's Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, China; Corresponding authors.Infertility has become one of the most common chronic diseases among reproductive- aged individuals, and male factors account for about 50 %. Zinc is a trace element that is essential for sperm quality and male reproductive system. Although several current studies with small sample sizes have investigated this relationship, the conclusions have been still controversial. Here, using a large population sample involved 25,915 participants from Changzhou Maternity and Child Health Care Hospital, we revealed an inverted “U”-shaped trend between seminal plasma zinc concentrations and sperm motility PR/PR + NP (PR, progressive motility; NP, non-progressive motility). The results showed that the highest values of sperm PR/PR + NP observed in the group with intermediate concentrations of zinc (Group 2, 0.25–2.11 mmol/L). The mean values were 43.17 ± 19.03 % and 56.64 ± 20.28 %, respectively. And the lowest values came out in the highest zinc levels group (Group 4, > 3.04 mmol/L). In vitro cell experiments also showed that zinc caused dose-dependent cytotoxicity for GC-2 cells at a threshold value. Furthermore, RNA-seq analysis demonstrated that high concentrations of zinc exerted toxic effects on GC-2 cells through immune injury. Taken together, our findings suggested that moderate amounts of zinc are crucial for human reproduction and excessive concentrations may have adverse effects on male fertility.http://www.sciencedirect.com/science/article/pii/S0147651324009655ZincSemen qualityToxic effectMale infertility |
| spellingShingle | Yu Chen Xiaoyu Wang Jing Zhou Ganlin Wang Tingting Gao Hai Wei Yurui Che Tianfu Li Zhenglin Zhang Shuxian Wang Lingmin Hu Renjie Lu Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility Ecotoxicology and Environmental Safety Zinc Semen quality Toxic effect Male infertility |
| title | Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility |
| title_full | Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility |
| title_fullStr | Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility |
| title_full_unstemmed | Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility |
| title_short | Association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility |
| title_sort | association of seminal plasma zinc levels with human semen quality and its toxic effects on sperm motility |
| topic | Zinc Semen quality Toxic effect Male infertility |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324009655 |
| work_keys_str_mv | AT yuchen associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT xiaoyuwang associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT jingzhou associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT ganlinwang associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT tingtinggao associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT haiwei associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT yuruiche associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT tianfuli associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT zhenglinzhang associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT shuxianwang associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT lingminhu associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility AT renjielu associationofseminalplasmazinclevelswithhumansemenqualityanditstoxiceffectsonspermmotility |