Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis
Objective To evaluate and analyze risk factors of arterial stiffness in patients given peritoneal dialysis.Methods A total of 86 patients with end-stage kidney disease undergoing peritoneal dialysis,19-60 years old,without diabetes mellitus were enrolled.Baseline characteristics,brachial-ankle pulse...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2016-01-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57918975&Fpath=home&index=0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849313159857307648 |
|---|---|
| author | SU Xiao-yan DING Su ZHENG Wei-ping ZOU Yuan-fang LI Ai-ting DENG Hui-zhao HUANG Hui |
| author_facet | SU Xiao-yan DING Su ZHENG Wei-ping ZOU Yuan-fang LI Ai-ting DENG Hui-zhao HUANG Hui |
| author_sort | SU Xiao-yan |
| collection | DOAJ |
| description | Objective To evaluate and analyze risk factors of arterial stiffness in patients given peritoneal dialysis.Methods A total of 86 patients with end-stage kidney disease undergoing peritoneal dialysis,19-60 years old,without diabetes mellitus were enrolled.Baseline characteristics,brachial-ankle pulse wave velocity（baPWV） and other laboratory measurements were collected and analyzed.BaPWV was determined using an automated,non-invasive,waveform analysis device.Results According to baPWV,the patients were divided into high baPWV group（baPWV>1 400 cm/s,n =39） and normal baPWV group（baPWV<1 400 cm/s,n = 47）.As compared with CAPD patients with normal levels of baPWV,the CAPD patients with high levels of baPWV had significantly higher baPWV[（1 961 ±412） cm/s vs.（1 349 + 234） cm/s,P<0.01],longer dialysis duration,higher ischemia modified albumin[IMA,（95.8 ± 6.0） kU/L],and higher sensitivity C-reactive protein[hsCRP,（5.1±1.0）mg/L].In addition,the high baPWV CAPD patients also had a lower level of total urea clearance index（Kt/V,1.8±0.9）,total creatinine clearance[（56.5±11.4）L·W<sup>-1</sup>·（1.73m<sup>2</sup>）<sup>-1</sup>],residual GFR[rGFR,（3.8±1.0）L·W<sup>-1</sup>·（1.73 m<sup>2</sup>）<sup>-1</sup>],and serum albumin[（31.6±5.3）g/L].The correlation analysis showed that baPWV was significantly correlated with dialysis duration,serum calcium,IMA and hs-CRP,and negatively with total Kt/V,rGFR and serum albumin（P<0.05）.Logistic regression analysis revealed that dialysis duration,rGFR and hs-CRP were the most significant factors affecting baPWV in PD patients.Conclusions Arterial stiffness,assessed by baPWV,had an independent correlation with dialysis duration,residual renal function,microinflammation in young and middle-aged non-diabetic patients undergoing peritoneal dialysis.To protect the residual renal function,improve the inflammatory state,and improve the adequacy of peritoneal dialysis can reduce the risk of atherosclerosis in patients with peritoneal dialysis,and reduce the incidence of cardiovascular events. |
| format | Article |
| id | doaj-art-e1920c95b68a45eb874a3a3e446bcf56 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2016-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-e1920c95b68a45eb874a3a3e446bcf562025-08-20T03:52:51ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902016-01-0120120557918975Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysisSU Xiao-yanDING SuZHENG Wei-pingZOU Yuan-fangLI Ai-tingDENG Hui-zhaoHUANG HuiObjective To evaluate and analyze risk factors of arterial stiffness in patients given peritoneal dialysis.Methods A total of 86 patients with end-stage kidney disease undergoing peritoneal dialysis,19-60 years old,without diabetes mellitus were enrolled.Baseline characteristics,brachial-ankle pulse wave velocity（baPWV） and other laboratory measurements were collected and analyzed.BaPWV was determined using an automated,non-invasive,waveform analysis device.Results According to baPWV,the patients were divided into high baPWV group（baPWV>1 400 cm/s,n =39） and normal baPWV group（baPWV<1 400 cm/s,n = 47）.As compared with CAPD patients with normal levels of baPWV,the CAPD patients with high levels of baPWV had significantly higher baPWV[（1 961 ±412） cm/s vs.（1 349 + 234） cm/s,P<0.01],longer dialysis duration,higher ischemia modified albumin[IMA,（95.8 ± 6.0） kU/L],and higher sensitivity C-reactive protein[hsCRP,（5.1±1.0）mg/L].In addition,the high baPWV CAPD patients also had a lower level of total urea clearance index（Kt/V,1.8±0.9）,total creatinine clearance[（56.5±11.4）L·W<sup>-1</sup>·（1.73m<sup>2</sup>）<sup>-1</sup>],residual GFR[rGFR,（3.8±1.0）L·W<sup>-1</sup>·（1.73 m<sup>2</sup>）<sup>-1</sup>],and serum albumin[（31.6±5.3）g/L].The correlation analysis showed that baPWV was significantly correlated with dialysis duration,serum calcium,IMA and hs-CRP,and negatively with total Kt/V,rGFR and serum albumin（P<0.05）.Logistic regression analysis revealed that dialysis duration,rGFR and hs-CRP were the most significant factors affecting baPWV in PD patients.Conclusions Arterial stiffness,assessed by baPWV,had an independent correlation with dialysis duration,residual renal function,microinflammation in young and middle-aged non-diabetic patients undergoing peritoneal dialysis.To protect the residual renal function,improve the inflammatory state,and improve the adequacy of peritoneal dialysis can reduce the risk of atherosclerosis in patients with peritoneal dialysis,and reduce the incidence of cardiovascular events.http://www.lcszb.com/thesisDetails?columnId=57918975&Fpath=home&index=0Peritoneal dialysisArterial stiffnessBrachial-ankle pulse wave velocity |
| spellingShingle | SU Xiao-yan DING Su ZHENG Wei-ping ZOU Yuan-fang LI Ai-ting DENG Hui-zhao HUANG Hui Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis Linchuang shenzangbing zazhi Peritoneal dialysis Arterial stiffness Brachial-ankle pulse wave velocity |
| title | Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis |
| title_full | Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis |
| title_fullStr | Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis |
| title_full_unstemmed | Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis |
| title_short | Evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis |
| title_sort | evaluation and risk factors of arterial stiffness in patients given peritoneal dialysis |
| topic | Peritoneal dialysis Arterial stiffness Brachial-ankle pulse wave velocity |
| url | http://www.lcszb.com/thesisDetails?columnId=57918975&Fpath=home&index=0 |
| work_keys_str_mv | AT suxiaoyan evaluationandriskfactorsofarterialstiffnessinpatientsgivenperitonealdialysis AT dingsu evaluationandriskfactorsofarterialstiffnessinpatientsgivenperitonealdialysis AT zhengweiping evaluationandriskfactorsofarterialstiffnessinpatientsgivenperitonealdialysis AT zouyuanfang evaluationandriskfactorsofarterialstiffnessinpatientsgivenperitonealdialysis AT liaiting evaluationandriskfactorsofarterialstiffnessinpatientsgivenperitonealdialysis AT denghuizhao evaluationandriskfactorsofarterialstiffnessinpatientsgivenperitonealdialysis AT huanghui evaluationandriskfactorsofarterialstiffnessinpatientsgivenperitonealdialysis |