EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF BENZOCAINE BY DICYCLOHEXYL-18-CROWN-6 AND CALMAGITE
A simple and sensitive extraction-spectrophotometric method for rapid and accurate determination of benzocaine in pure and dosage forms was developed. Benzocaine was effectively extracted as a 1:1 ion pair complex with dicyclohexyl-18-crown-6 and calmagite in acidic media into chloroform, followed b...
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| Format: | Article |
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| Language: | English |
| Published: |
University of Tehran
2002-06-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31739_84e9aba91ea9adcf91bb33dbe5dc08b4.pdf |
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| Summary: | A simple and sensitive extraction-spectrophotometric method for rapid and accurate determination of benzocaine in pure and dosage forms was developed. Benzocaine was effectively extracted as a 1:1 ion pair complex with dicyclohexyl-18-crown-6 and calmagite in acidic media into chloroform, followed by spectrophotometric determination at 486 nm. Molar absorptivity of the ternary complex at this wavelength was 5.25×103 l mol-1 cm-1. Beer’s law was obeyed over the range 1.65-132 µg/ml of benzocaine and the minimum detectable amount of the drug was 0.6 µg/ml. The method was successfully applied to the determination of benzocaine in a cream sample. |
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| ISSN: | 1016-1104 2345-6914 |