ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS
Periodontitis is a chronic infectious inflammatory disease, being the most common bone disease in humans. Porphyromonas gingivalis bacteria are quite common in periodontal lesions, thus considered among major causal agents of periodontitis. Monocytes play a crucial role in development of the infecti...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-08-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/682 |
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| author | L. M. Tebloeva O. A. Guseva S. V. Philippov S. V. Khaidukov |
| author_facet | L. M. Tebloeva O. A. Guseva S. V. Philippov S. V. Khaidukov |
| author_sort | L. M. Tebloeva |
| collection | DOAJ |
| description | Periodontitis is a chronic infectious inflammatory disease, being the most common bone disease in humans. Porphyromonas gingivalis bacteria are quite common in periodontal lesions, thus considered among major causal agents of periodontitis. Monocytes play a crucial role in development of the infectious events and subsequent inflammation. The aim of this study was to investigate appropriate changes of the monocyte subpopulations, as well as to assess relationships between expression of CD14, CD16, CD45RA, HLA-DR on the monocyte surfaces in the patients with periodontitis. It was demonstrated that periodontitis is accompanied by increased counts of pro-inflammatory monocytes. These changes are characterized by decreased expression of CD14, along with occurence of CD16 marker. Concomitant activation of the monocytes is reflected by CD45RA expression. However, in spite of significant increase in CD14lowCD16+HLA-DR+ cell counts observed in patients with periodontitis, these monocyte populations are not likely to play a significant role in development of a specific immune response and suppression of periodontitis. |
| format | Article |
| id | doaj-art-e18cc7bbee3646db8ac9ef09e7ba7acd |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-e18cc7bbee3646db8ac9ef09e7ba7acd2025-08-20T03:37:46ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-08-0116216517210.15789/1563-0625-2014-2-165-172679ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITISL. M. Tebloeva0O. A. Guseva1S. V. Philippov2S. V. Khaidukov3Moscow A.I. Evdokimov University of Medical Dentistry, MoscowDmitry Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health Care, MoscowRussian Children’s Clinical Hospital, Ministry of Health Care, MoscowM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bio-Organic Chemistry, Russian Academy of Sciences, MoscowPeriodontitis is a chronic infectious inflammatory disease, being the most common bone disease in humans. Porphyromonas gingivalis bacteria are quite common in periodontal lesions, thus considered among major causal agents of periodontitis. Monocytes play a crucial role in development of the infectious events and subsequent inflammation. The aim of this study was to investigate appropriate changes of the monocyte subpopulations, as well as to assess relationships between expression of CD14, CD16, CD45RA, HLA-DR on the monocyte surfaces in the patients with periodontitis. It was demonstrated that periodontitis is accompanied by increased counts of pro-inflammatory monocytes. These changes are characterized by decreased expression of CD14, along with occurence of CD16 marker. Concomitant activation of the monocytes is reflected by CD45RA expression. However, in spite of significant increase in CD14lowCD16+HLA-DR+ cell counts observed in patients with periodontitis, these monocyte populations are not likely to play a significant role in development of a specific immune response and suppression of periodontitis.https://www.mimmun.ru/mimmun/article/view/682flow cytometrymonocytesperiodontitiscd14cd16 |
| spellingShingle | L. M. Tebloeva O. A. Guseva S. V. Philippov S. V. Khaidukov ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS Медицинская иммунология flow cytometry monocytes periodontitis cd14 cd16 |
| title | ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS |
| title_full | ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS |
| title_fullStr | ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS |
| title_full_unstemmed | ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS |
| title_short | ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS |
| title_sort | activation and differentiation of peripheral blood monocytes in periodontitis |
| topic | flow cytometry monocytes periodontitis cd14 cd16 |
| url | https://www.mimmun.ru/mimmun/article/view/682 |
| work_keys_str_mv | AT lmtebloeva activationanddifferentiationofperipheralbloodmonocytesinperiodontitis AT oaguseva activationanddifferentiationofperipheralbloodmonocytesinperiodontitis AT svphilippov activationanddifferentiationofperipheralbloodmonocytesinperiodontitis AT svkhaidukov activationanddifferentiationofperipheralbloodmonocytesinperiodontitis |