The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea
Background: Endometrial inflammation factors play a crucial role in the common pathophysiology of primary dysmenorrhea. Malondialdehyde (MDA), a byproduct of inflammatory processes, might be correlated with primary dysmenorrhea in adolescents. Objective: To assess plasma MDA levels in patients w...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indonesian Society for Biochemistry and Molecular Biology
2023-09-01
|
| Series: | Acta Biochimica Indonesiana |
| Subjects: | |
| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/119 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825199617861484544 |
|---|---|
| author | Ocktariyana Ocktariyana Dian Lestari Abdul Kadir Listrianah Listrianah Handayani Handayani |
| author_facet | Ocktariyana Ocktariyana Dian Lestari Abdul Kadir Listrianah Listrianah Handayani Handayani |
| author_sort | Ocktariyana Ocktariyana |
| collection | DOAJ |
| description |
Background: Endometrial inflammation factors play a crucial role in the common pathophysiology of primary dysmenorrhea. Malondialdehyde (MDA), a byproduct of inflammatory processes, might be correlated with primary dysmenorrhea in adolescents.
Objective: To assess plasma MDA levels in patients with primary dysmenorrhea.
Methods: This cross-sectional study involved the collection of blood samples from 23 teenage females with primary dysmenorrhea and 23 age-matched individuals without this condition. Plasma MDA levels were quantified through spectrophotometry. The independent t-test was employed to ascertain the disparity in plasma MDA levels between the two groups, while the Pearson correlation test was utilized to analyze the relationship between pain severity and oxidative stress levels.
Results: Plasma MDA levels were significantly higher in females with primary dysmenorrhea than in the control group (0.631 ± 0.105 and 0.395 ± 0.076, respectively). A significant difference in oxidative stress levels was observed between the case and control groups (p<0.001). Furthermore, a robust positive correlation was observed between plasma MDA levels and pain severity in adolescent females with dysmenorrhea (r2 = 0.564, p<0.001).
Conclusion: The plasma MDA is increased in adolescent females with primary dysmenorrhea.
|
| format | Article |
| id | doaj-art-e18bc8ef88d447e6ad1d9649a9f3d96f |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-e18bc8ef88d447e6ad1d9649a9f3d96f2025-02-08T03:05:54ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222023-09-016110.32889/actabioina.119The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrheaOcktariyana Ocktariyana0Dian Lestari1Abdul Kadir2Listrianah Listrianah3Handayani Handayani4Department of Midwifery, Politeknik Kesehatan Kementerian Kesehatan Palembang, Palembang, 30114, IndonesiaDepartment of Midwifery, Poltekkes Kemenkes Palembang, Palembang, 30114, IndonesiaDepartment of Midwifery, Poltekkes Kemenkes Palembang, Palembang, 30114, IndonesiaDepartment of Dental Health, Poltekkes Kemenkes Palembang, Palembang, 30114, IndonesiaDepartment of Medical Laboratory Technology, Poltekkes Kemenkes Palembang, Palembang, 30114, Indonesia Background: Endometrial inflammation factors play a crucial role in the common pathophysiology of primary dysmenorrhea. Malondialdehyde (MDA), a byproduct of inflammatory processes, might be correlated with primary dysmenorrhea in adolescents. Objective: To assess plasma MDA levels in patients with primary dysmenorrhea. Methods: This cross-sectional study involved the collection of blood samples from 23 teenage females with primary dysmenorrhea and 23 age-matched individuals without this condition. Plasma MDA levels were quantified through spectrophotometry. The independent t-test was employed to ascertain the disparity in plasma MDA levels between the two groups, while the Pearson correlation test was utilized to analyze the relationship between pain severity and oxidative stress levels. Results: Plasma MDA levels were significantly higher in females with primary dysmenorrhea than in the control group (0.631 ± 0.105 and 0.395 ± 0.076, respectively). A significant difference in oxidative stress levels was observed between the case and control groups (p<0.001). Furthermore, a robust positive correlation was observed between plasma MDA levels and pain severity in adolescent females with dysmenorrhea (r2 = 0.564, p<0.001). Conclusion: The plasma MDA is increased in adolescent females with primary dysmenorrhea. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/119Malondialdehydeoxidative stressprimary dysmenorrhea |
| spellingShingle | Ocktariyana Ocktariyana Dian Lestari Abdul Kadir Listrianah Listrianah Handayani Handayani The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea Acta Biochimica Indonesiana Malondialdehyde oxidative stress primary dysmenorrhea |
| title | The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea |
| title_full | The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea |
| title_fullStr | The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea |
| title_full_unstemmed | The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea |
| title_short | The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea |
| title_sort | correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea |
| topic | Malondialdehyde oxidative stress primary dysmenorrhea |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/119 |
| work_keys_str_mv | AT ocktariyanaocktariyana thecorrelationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT dianlestari thecorrelationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT abdulkadir thecorrelationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT listrianahlistrianah thecorrelationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT handayanihandayani thecorrelationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT ocktariyanaocktariyana correlationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT dianlestari correlationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT abdulkadir correlationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT listrianahlistrianah correlationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea AT handayanihandayani correlationbetweenplasmamalondialdehydelevelsandpaininadolescentfemalesdiagnosedwithprimarydysmenorrhea |