Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study
The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2022/4382145 |
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| author | Jincheol Seo Kyung Seob Lim Chang-Yeop Jeon SeungHo Baek Hyeon-Gu Yeo Won Seok Choi Sung-Hyun Park Kang Jin Jeong Jinyoung Won Keonwoo Kim Junghyung Park Jiyeon Cho Jung Bae Seong Minji Kim Yu Gyeong Kim Jae-Won Huh Samhwan Kim Yong Hoon Lim Hyung Woo Park Hye Min Tak Man Seong Heo Ji-Woong Choi Sun Ha Paek Youngjeon Lee |
| author_facet | Jincheol Seo Kyung Seob Lim Chang-Yeop Jeon SeungHo Baek Hyeon-Gu Yeo Won Seok Choi Sung-Hyun Park Kang Jin Jeong Jinyoung Won Keonwoo Kim Junghyung Park Jiyeon Cho Jung Bae Seong Minji Kim Yu Gyeong Kim Jae-Won Huh Samhwan Kim Yong Hoon Lim Hyung Woo Park Hye Min Tak Man Seong Heo Ji-Woong Choi Sun Ha Paek Youngjeon Lee |
| author_sort | Jincheol Seo |
| collection | DOAJ |
| description | The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To investigate whether MPTP-induced unilaterally damaged regions were determined by asymmetrical cerebral blood flow, the differential asymmetric damage of striatal subregions, and examined structural asymmetries in a circle of Willis, and blood flow velocity of the common carotid artery were observed in three monkeys that were infused with MPTP through the left internal carotid artery. Lower flow velocity in the ipsilateral common carotid artery and a higher ratio of ipsilateral middle cerebral artery diameter to anterior cerebral artery diameter resulted in unilateral damage. Additionally, the unilateral damaged monkey observed the apomorphine-induced contralateral rotation behavior and the temporary increase of plasma RANTES. Contrastively, higher flow velocity in the ipsilateral common carotid artery was observed in the bilateral damaged monkey. It is suggested that asymmetry of blood flow velocity and structural asymmetry of the circle of Willis should be taken into consideration when establishing more efficient hemiparkinsonian nonhuman primate models. |
| format | Article |
| id | doaj-art-e184de2df2f743b4a3850a8b75c98e5a |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-e184de2df2f743b4a3850a8b75c98e5a2025-02-03T06:13:34ZengWileyParkinson's Disease2042-00802022-01-01202210.1155/2022/4382145Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot StudyJincheol Seo0Kyung Seob Lim1Chang-Yeop Jeon2SeungHo Baek3Hyeon-Gu Yeo4Won Seok Choi5Sung-Hyun Park6Kang Jin Jeong7Jinyoung Won8Keonwoo Kim9Junghyung Park10Jiyeon Cho11Jung Bae Seong12Minji Kim13Yu Gyeong Kim14Jae-Won Huh15Samhwan Kim16Yong Hoon Lim17Hyung Woo Park18Hye Min Tak19Man Seong Heo20Ji-Woong Choi21Sun Ha Paek22Youngjeon Lee23National Primate Research CenterFuturistic Animal Resource and Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterNational Primate Research CenterBrain Engineering Convergence Research CenterMovement Disorder CenterDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of Information and Communication EngineeringMovement Disorder CenterNational Primate Research CenterThe hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To investigate whether MPTP-induced unilaterally damaged regions were determined by asymmetrical cerebral blood flow, the differential asymmetric damage of striatal subregions, and examined structural asymmetries in a circle of Willis, and blood flow velocity of the common carotid artery were observed in three monkeys that were infused with MPTP through the left internal carotid artery. Lower flow velocity in the ipsilateral common carotid artery and a higher ratio of ipsilateral middle cerebral artery diameter to anterior cerebral artery diameter resulted in unilateral damage. Additionally, the unilateral damaged monkey observed the apomorphine-induced contralateral rotation behavior and the temporary increase of plasma RANTES. Contrastively, higher flow velocity in the ipsilateral common carotid artery was observed in the bilateral damaged monkey. It is suggested that asymmetry of blood flow velocity and structural asymmetry of the circle of Willis should be taken into consideration when establishing more efficient hemiparkinsonian nonhuman primate models.http://dx.doi.org/10.1155/2022/4382145 |
| spellingShingle | Jincheol Seo Kyung Seob Lim Chang-Yeop Jeon SeungHo Baek Hyeon-Gu Yeo Won Seok Choi Sung-Hyun Park Kang Jin Jeong Jinyoung Won Keonwoo Kim Junghyung Park Jiyeon Cho Jung Bae Seong Minji Kim Yu Gyeong Kim Jae-Won Huh Samhwan Kim Yong Hoon Lim Hyung Woo Park Hye Min Tak Man Seong Heo Ji-Woong Choi Sun Ha Paek Youngjeon Lee Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study Parkinson's Disease |
| title | Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study |
| title_full | Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study |
| title_fullStr | Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study |
| title_full_unstemmed | Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study |
| title_short | Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study |
| title_sort | determination of the unilaterally damaged region may depend on the asymmetry of carotid blood flow velocity in hemiparkinsonian monkey a pilot study |
| url | http://dx.doi.org/10.1155/2022/4382145 |
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