Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer
Introduction. Researchers in the field of oncology have a significant interest in the role of microorganisms in development of malignant neoplasms.Aim. To study the levels of 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-quinolone (HHQ) produced by Pseudomonas aeruginosa in the blood of patien...
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ABV-press
2023-07-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/548 |
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| author | A. V. Shestopalov O. I. Кit V. V. Davydov Ya. M. Baizyanova E. Yu. Zlatnik I. A. Novikova A. B. Sagakyants S. A. Appolonova N. E. Moskaleva S. A. Rumyantsev |
| author_facet | A. V. Shestopalov O. I. Кit V. V. Davydov Ya. M. Baizyanova E. Yu. Zlatnik I. A. Novikova A. B. Sagakyants S. A. Appolonova N. E. Moskaleva S. A. Rumyantsev |
| author_sort | A. V. Shestopalov |
| collection | DOAJ |
| description | Introduction. Researchers in the field of oncology have a significant interest in the role of microorganisms in development of malignant neoplasms.Aim. To study the levels of 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-quinolone (HHQ) produced by Pseudomonas aeruginosa in the blood of patients with lung cancer and to analyze the relation between their changes and changes in the level of immunoglobulins and vascular endothelial growth factor (VEGF) in the blood of patients with lung cancer.Materials and methods. PQS and HHQ were quantified in the blood of patients using high performance liquid chromatography. The levels of immunoglobulins G (IgG), secretory immunoglobulin A (s-IgA), and VEGF in the blood were determined using ELISA.Results. Analysis have shown that the level of PQS in the blood of patients with lung cancer is 2-fold higher than in the control group. This change is accompanied by a decrease in the level of immunoglobulins IgG, as well as an increase in the content of s-IgA and growth factor VEGF in the blood.Conclusion. PQS level in the blood of patients with lung cancer is elevated creating conditions aggravating the course of the main disease and worsening its prognosis. |
| format | Article |
| id | doaj-art-e1837b78a6df49ec971b2228fe4ce87d |
| institution | Kabale University |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-e1837b78a6df49ec971b2228fe4ce87d2025-08-20T03:38:02ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872023-07-0110212613110.17650/2313-805X-2023-10-2-126-131288Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancerA. V. Shestopalov0O. I. Кit1V. V. Davydov2Ya. M. Baizyanova3E. Yu. Zlatnik4I. A. Novikova5A. B. Sagakyants6S. A. Appolonova7N. E. Moskaleva8S. A. Rumyantsev9Pirogov Russian National Research Medical University, Ministry of Health of Russia; Center of Digital and Translational Biomedicine, Сenter of Molecular HealthNational Medical Research Center of Oncology, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaNational Medical Research Center of Oncology, Ministry of Health of RussiaNational Medical Research Center of Oncology, Ministry of Health of RussiaNational Medical Research Center of Oncology, Ministry of Health of RussiaCenter of Digital and Translational Biomedicine, Сenter of Molecular HealthCenter of Digital and Translational Biomedicine, Сenter of Molecular HealthPirogov Russian National Research Medical University, Ministry of Health of Russia; Center of Digital and Translational Biomedicine, Сenter of Molecular HealthIntroduction. Researchers in the field of oncology have a significant interest in the role of microorganisms in development of malignant neoplasms.Aim. To study the levels of 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-quinolone (HHQ) produced by Pseudomonas aeruginosa in the blood of patients with lung cancer and to analyze the relation between their changes and changes in the level of immunoglobulins and vascular endothelial growth factor (VEGF) in the blood of patients with lung cancer.Materials and methods. PQS and HHQ were quantified in the blood of patients using high performance liquid chromatography. The levels of immunoglobulins G (IgG), secretory immunoglobulin A (s-IgA), and VEGF in the blood were determined using ELISA.Results. Analysis have shown that the level of PQS in the blood of patients with lung cancer is 2-fold higher than in the control group. This change is accompanied by a decrease in the level of immunoglobulins IgG, as well as an increase in the content of s-IgA and growth factor VEGF in the blood.Conclusion. PQS level in the blood of patients with lung cancer is elevated creating conditions aggravating the course of the main disease and worsening its prognosis.https://umo.abvpress.ru/jour/article/view/548lung cancer2-heptyl-3-hydroxy-4-quinolone2-heptyl-4-quinolonecytokinesimmunoglobulins<i>pseudomonas aeruginosa</i>quorum sensing |
| spellingShingle | A. V. Shestopalov O. I. Кit V. V. Davydov Ya. M. Baizyanova E. Yu. Zlatnik I. A. Novikova A. B. Sagakyants S. A. Appolonova N. E. Moskaleva S. A. Rumyantsev Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer Успехи молекулярной онкологии lung cancer 2-heptyl-3-hydroxy-4-quinolone 2-heptyl-4-quinolone cytokines immunoglobulins <i>pseudomonas aeruginosa</i> quorum sensing |
| title | Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer |
| title_full | Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer |
| title_fullStr | Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer |
| title_full_unstemmed | Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer |
| title_short | Interrelation between <i>Pseudomonas aeruginosa</i> quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer |
| title_sort | interrelation between i pseudomonas aeruginosa i quinolone signal and the level of immunoglobulins in the blood of patients with lung cancer |
| topic | lung cancer 2-heptyl-3-hydroxy-4-quinolone 2-heptyl-4-quinolone cytokines immunoglobulins <i>pseudomonas aeruginosa</i> quorum sensing |
| url | https://umo.abvpress.ru/jour/article/view/548 |
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