PPARGC1A regulates transcriptional control of mitochondrial biogenesis in early bovine embryos

PPARGC1A regulates transcriptional control of mitochondrial biogenesis in early bovine embryos

Extensive mitochondrial replication during oogenesis and its role in oocyte maturation and fertilization indicate that the amount of mitochondrial DNA (mtDNA) may play a significant role in early embryonic development. Early embryos express peroxisome proliferator-activated receptor gamma co-activat...

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Bibliographic Details
Main Authors: Muhammad Idrees, Zaheer Haider, Chalani Dilshani Perera, Safeer Ullah, Seo-Hyeon Lee, Seung Eun Lee, Sung-Sik Kang, Sung Woo Kim, Il-Keun Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PGC-1α
mitochondrial DNA
TFAM
NRF
bovine blastocyst
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1531378/full
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