Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier
Skin photoaging, a process with substantial physical and psychological impacts, is also a recognized risk factor for skin cancer. Despite advancements in dermatological research, effective prevention and reversal of photoaging remain challenging. This study investigated the efficacy of CyRL-QN15, an...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132500805X |
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| author | Zijian Kang Saige Yin Xiaoya Han Xin Liu Ying Peng Qiuye Jia Zhe Fu Yuansheng Li Yutong Wu Zhaoxun Xiao Zhiruo Li Ying Wang Mingying Luo Xinwang Yang |
| author_facet | Zijian Kang Saige Yin Xiaoya Han Xin Liu Ying Peng Qiuye Jia Zhe Fu Yuansheng Li Yutong Wu Zhaoxun Xiao Zhiruo Li Ying Wang Mingying Luo Xinwang Yang |
| author_sort | Zijian Kang |
| collection | DOAJ |
| description | Skin photoaging, a process with substantial physical and psychological impacts, is also a recognized risk factor for skin cancer. Despite advancements in dermatological research, effective prevention and reversal of photoaging remain challenging. This study investigated the efficacy of CyRL-QN15, an optimized variant derived from the RL-QN15 peptide, in mitigating ultraviolet B (UVB)-induced skin photoaging in mice. Results showed that CyRL-QN15 promoted skin barrier repair and exhibited antioxidant and anti-apoptotic properties. Mechanistically, these effects were mediated by activating the downstream Wnt/β-catenin signaling pathway. Notably, the therapeutic efficacy of CyRL-QN15 was diminished by using the inhibitor MSAB, suggesting a crucial role for the β-catenin signaling pathway. Furthermore, CyRL-QN15 may exert its effects by binding to the Frizzled-8 receptor on the human keratinocyte (HaCaT) cell membranes. This study is the first to identify the role of β-catenin regulation in skin barrier dysfunction during photoaging, establishing a potential therapeutic foundation for targeting CyRL-QN15 to combat skin photoaging. |
| format | Article |
| id | doaj-art-e17f5f250a0e4a2982a5d2898e3cffc6 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e17f5f250a0e4a2982a5d2898e3cffc62025-08-20T03:45:28ZengElsevierEcotoxicology and Environmental Safety0147-65132025-07-0130011846510.1016/j.ecoenv.2025.118465Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrierZijian Kang0Saige Yin1Xiaoya Han2Xin Liu3Ying Peng4Qiuye Jia5Zhe Fu6Yuansheng Li7Yutong Wu8Zhaoxun Xiao9Zhiruo Li10Ying Wang11Mingying Luo12Xinwang Yang13Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaDepartment of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, ChinaKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan 650504, China; Corresponding authors.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China; Corresponding authors.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China; Corresponding authors.Skin photoaging, a process with substantial physical and psychological impacts, is also a recognized risk factor for skin cancer. Despite advancements in dermatological research, effective prevention and reversal of photoaging remain challenging. This study investigated the efficacy of CyRL-QN15, an optimized variant derived from the RL-QN15 peptide, in mitigating ultraviolet B (UVB)-induced skin photoaging in mice. Results showed that CyRL-QN15 promoted skin barrier repair and exhibited antioxidant and anti-apoptotic properties. Mechanistically, these effects were mediated by activating the downstream Wnt/β-catenin signaling pathway. Notably, the therapeutic efficacy of CyRL-QN15 was diminished by using the inhibitor MSAB, suggesting a crucial role for the β-catenin signaling pathway. Furthermore, CyRL-QN15 may exert its effects by binding to the Frizzled-8 receptor on the human keratinocyte (HaCaT) cell membranes. This study is the first to identify the role of β-catenin regulation in skin barrier dysfunction during photoaging, establishing a potential therapeutic foundation for targeting CyRL-QN15 to combat skin photoaging.http://www.sciencedirect.com/science/article/pii/S014765132500805XUVB irradiationSkin agingSkin barrier repairPeptidesFrizzled-8 receptorRana limnocharis |
| spellingShingle | Zijian Kang Saige Yin Xiaoya Han Xin Liu Ying Peng Qiuye Jia Zhe Fu Yuansheng Li Yutong Wu Zhaoxun Xiao Zhiruo Li Ying Wang Mingying Luo Xinwang Yang Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier Ecotoxicology and Environmental Safety UVB irradiation Skin aging Skin barrier repair Peptides Frizzled-8 receptor Rana limnocharis |
| title | Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier |
| title_full | Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier |
| title_fullStr | Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier |
| title_full_unstemmed | Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier |
| title_short | Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier |
| title_sort | peptide cyrl qn15 alleviates uvb induced skin aging by promoting the repair of barrier |
| topic | UVB irradiation Skin aging Skin barrier repair Peptides Frizzled-8 receptor Rana limnocharis |
| url | http://www.sciencedirect.com/science/article/pii/S014765132500805X |
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