Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies
ABSTRACT Background Mitochondria play a critical role in cellular bioenergetics and signaling, with particular importance in the context of reproductive biology. This review summarizes their role in reproduction and explores current and emerging mitochondrial therapies for fertility treatment. Metho...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12672 |
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| author | Sanath Udayanga Kankanam Gamage Yoshiharu Morimoto |
| author_facet | Sanath Udayanga Kankanam Gamage Yoshiharu Morimoto |
| author_sort | Sanath Udayanga Kankanam Gamage |
| collection | DOAJ |
| description | ABSTRACT Background Mitochondria play a critical role in cellular bioenergetics and signaling, with particular importance in the context of reproductive biology. This review summarizes their role in reproduction and explores current and emerging mitochondrial therapies for fertility treatment. Methods A comprehensive literature search using terms like mitochondria, infertility, reproduction, gametes, mitochondrial replacement, and mitochondrial transplantation identified relevant studies on mitochondria's role in gametogenesis, fertilization, and early embryonic development in relevant databases. Selected publications were reviewed and summarized to present current and future mitochondrial therapies for fertility. Main Findings Mitochondrial dynamics and functions are critical for meeting the energy requirements of essential reproductive processes, including gametogenesis, fertilization, and early embryonic development. Dysregulation of mitochondrial function has been associated with a range of reproductive disorders, such as infertility, recurrent pregnancy loss, and maternally inherited mitochondrial diseases. Emerging therapeutic strategies, such as mitochondrial replacement therapy, antioxidant supplementation, and mitochondrial transplantation, offer promising avenues for overcoming these challenges and improving reproductive outcomes. Conclusions Utilizing mitochondrial‐based therapies represents a promising and innovative approach in the advancement of fertility treatments. Ongoing research and clinical development in this area hold significant potential to enhance reproductive outcomes and improve the quality of life for individuals and couples facing fertility challenges. |
| format | Article |
| id | doaj-art-e17f3d7cfb8140f99188874830a3a2b2 |
| institution | Kabale University |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-e17f3d7cfb8140f99188874830a3a2b22025-08-20T06:16:47ZengWileyReproductive Medicine and Biology1445-57811447-05782025-01-01241n/an/a10.1002/rmb2.12672Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive TechnologiesSanath Udayanga Kankanam Gamage0Yoshiharu Morimoto1HORAC Grand Front Osaka Clinic Osaka JapanHORAC Grand Front Osaka Clinic Osaka JapanABSTRACT Background Mitochondria play a critical role in cellular bioenergetics and signaling, with particular importance in the context of reproductive biology. This review summarizes their role in reproduction and explores current and emerging mitochondrial therapies for fertility treatment. Methods A comprehensive literature search using terms like mitochondria, infertility, reproduction, gametes, mitochondrial replacement, and mitochondrial transplantation identified relevant studies on mitochondria's role in gametogenesis, fertilization, and early embryonic development in relevant databases. Selected publications were reviewed and summarized to present current and future mitochondrial therapies for fertility. Main Findings Mitochondrial dynamics and functions are critical for meeting the energy requirements of essential reproductive processes, including gametogenesis, fertilization, and early embryonic development. Dysregulation of mitochondrial function has been associated with a range of reproductive disorders, such as infertility, recurrent pregnancy loss, and maternally inherited mitochondrial diseases. Emerging therapeutic strategies, such as mitochondrial replacement therapy, antioxidant supplementation, and mitochondrial transplantation, offer promising avenues for overcoming these challenges and improving reproductive outcomes. Conclusions Utilizing mitochondrial‐based therapies represents a promising and innovative approach in the advancement of fertility treatments. Ongoing research and clinical development in this area hold significant potential to enhance reproductive outcomes and improve the quality of life for individuals and couples facing fertility challenges.https://doi.org/10.1002/rmb2.12672ascentinfertilitymitochondriamitochondrial dysfunctionmitochondrial therapies for infertilitymitochondrial transplantation |
| spellingShingle | Sanath Udayanga Kankanam Gamage Yoshiharu Morimoto Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies Reproductive Medicine and Biology ascent infertility mitochondria mitochondrial dysfunction mitochondrial therapies for infertility mitochondrial transplantation |
| title | Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies |
| title_full | Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies |
| title_fullStr | Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies |
| title_full_unstemmed | Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies |
| title_short | Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies |
| title_sort | significance of mitochondrial dynamics in reproductive physiology current and emerging horizons in mitochondrial therapy for assisted reproductive technologies |
| topic | ascent infertility mitochondria mitochondrial dysfunction mitochondrial therapies for infertility mitochondrial transplantation |
| url | https://doi.org/10.1002/rmb2.12672 |
| work_keys_str_mv | AT sanathudayangakankanamgamage significanceofmitochondrialdynamicsinreproductivephysiologycurrentandemerginghorizonsinmitochondrialtherapyforassistedreproductivetechnologies AT yoshiharumorimoto significanceofmitochondrialdynamicsinreproductivephysiologycurrentandemerginghorizonsinmitochondrialtherapyforassistedreproductivetechnologies |