Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response
Sepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI). Renqing Changjue (RQCJ), a renowned prescription in traditional Tibetan medicine, is reported to have anti-inflammatory effects. The present stu...
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Elsevier
2025-05-01
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| Series: | Immunobiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171298525000178 |
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| author | Minxia Zhu Yaqi Lei Zhaojun Zhang Xu Guo Jing Guo Ruipeng Wu Xiaofeng Li Shibo Tian Yuanhao Zhao |
| author_facet | Minxia Zhu Yaqi Lei Zhaojun Zhang Xu Guo Jing Guo Ruipeng Wu Xiaofeng Li Shibo Tian Yuanhao Zhao |
| author_sort | Minxia Zhu |
| collection | DOAJ |
| description | Sepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI). Renqing Changjue (RQCJ), a renowned prescription in traditional Tibetan medicine, is reported to have anti-inflammatory effects. The present study was aimed at exploring whether RQCJ could mitigate sepsis-induced ALI and elucidating its underlying mechanism. The rat model of sepsis-induced ALI was established by intraperitoneal injection of lipopolysaccharide (LPS), and high, medium, and low doses of RQCJ were administered. The results indicated that the intervention of RQCJ improved septic symptoms, mitigated the murine sepsis score and pulmonary edema in LPS-induced septic rats, and decreased inflammatory cytokines in lung tissue such as interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1). Furthermore, RQCJ regulated the balance of renin-angiotensin system by enhancing the enzyme activity of angiotensin converting enzyme 2 (ACE2) while inhibiting ACE, thereby promoting the production of angiotensin 1–7 (Ang1–7). This study highlights the multiple protective effects of RQCJ on sepsis-induced ALI, providing a valuable reference for its further development and offering a novel perspective for the treatment of sepsis-induced ALI. |
| format | Article |
| id | doaj-art-e17e063cd1c14aaba190bd391c418cc9 |
| institution | OA Journals |
| issn | 0171-2985 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Immunobiology |
| spelling | doaj-art-e17e063cd1c14aaba190bd391c418cc92025-08-20T02:32:33ZengElsevierImmunobiology0171-29852025-05-01230315288310.1016/j.imbio.2025.152883Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory responseMinxia Zhu0Yaqi Lei1Zhaojun Zhang2Xu Guo3Jing Guo4Ruipeng Wu5Xiaofeng Li6Shibo Tian7Yuanhao Zhao8Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China; Corresponding author at: School of Medicine, Xizang Minzu University, Wenhui East Road 6, Weicheng District, Xianyang 712082, Shaanxi, China.Affiliated Hospital of Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaKey Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaKey Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaKey Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaKey Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaKey Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaKey Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaKey Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, ChinaSepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI). Renqing Changjue (RQCJ), a renowned prescription in traditional Tibetan medicine, is reported to have anti-inflammatory effects. The present study was aimed at exploring whether RQCJ could mitigate sepsis-induced ALI and elucidating its underlying mechanism. The rat model of sepsis-induced ALI was established by intraperitoneal injection of lipopolysaccharide (LPS), and high, medium, and low doses of RQCJ were administered. The results indicated that the intervention of RQCJ improved septic symptoms, mitigated the murine sepsis score and pulmonary edema in LPS-induced septic rats, and decreased inflammatory cytokines in lung tissue such as interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1). Furthermore, RQCJ regulated the balance of renin-angiotensin system by enhancing the enzyme activity of angiotensin converting enzyme 2 (ACE2) while inhibiting ACE, thereby promoting the production of angiotensin 1–7 (Ang1–7). This study highlights the multiple protective effects of RQCJ on sepsis-induced ALI, providing a valuable reference for its further development and offering a novel perspective for the treatment of sepsis-induced ALI.http://www.sciencedirect.com/science/article/pii/S0171298525000178Renqing ChangjueSepsis-induced acute lung injuryRenin-angiotensin systemInflammatory cytokines |
| spellingShingle | Minxia Zhu Yaqi Lei Zhaojun Zhang Xu Guo Jing Guo Ruipeng Wu Xiaofeng Li Shibo Tian Yuanhao Zhao Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response Immunobiology Renqing Changjue Sepsis-induced acute lung injury Renin-angiotensin system Inflammatory cytokines |
| title | Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response |
| title_full | Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response |
| title_fullStr | Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response |
| title_full_unstemmed | Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response |
| title_short | Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response |
| title_sort | renqing changjue alleviates sepsis induced acute lung injury by regulating renin angiotensin system and inhibiting inflammatory response |
| topic | Renqing Changjue Sepsis-induced acute lung injury Renin-angiotensin system Inflammatory cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S0171298525000178 |
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