Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018
PurposeThe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a crucial lipid marker associated with various cardiovascular diseases. However, its relationship with kidney injury, particularly albuminuria, remains poorly understood. This study aims to in...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1503780/full |
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| author | Dongli Huang Yuan He |
| author_facet | Dongli Huang Yuan He |
| author_sort | Dongli Huang |
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| description | PurposeThe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a crucial lipid marker associated with various cardiovascular diseases. However, its relationship with kidney injury, particularly albuminuria, remains poorly understood. This study aims to investigate the association between NHHR and macroalbuminuria in U.S. adultsPatients and methodsThis cross-sectional study utilized data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES). NHHR was calculated as (Total cholesterol - HDL cholesterol)/HDL cholesterol. Macroalbuminuria was defined by an albumin-creatinine ratio (ACR) >300 mg/g. Logistic regression, smoothed curve fitting, subgroup analyses, and sensitivity analysis were employed to assess the relationship between NHHR and macroalbuminuria.ResultsA total of 41,225 participants were included in the analysis. Higher NHHR was significantly associated with an increased likelihood of macroalbuminuria (OR = 1.34, 95% CI: 1.13–1.59, p=0.0007). Subgroup analysis revealed a stronger association in participants with BMI ≥30 kg/m2(OR = 1.89, 95% CI: 1.44–2.47, p<0.01). Sensitivity analysis revealed that the association remained robust even after excluding participants taking medications that affect lipid metabolism.ConclusionIn U.S. adults, an increased likelihood of incident NHHR levels of macroalbuminuria is positively associated and is more pronounced in those with a BMI ≥30kg/m2. |
| format | Article |
| id | doaj-art-e17686276b134d18bb84ba8d5dabc884 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-e17686276b134d18bb84ba8d5dabc8842025-02-11T09:54:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15037801503780Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018Dongli Huang0Yuan He1Department of Nephrology, Bishan Hospital of Chongqing Medical University (Bishan Hospital of Chongqing), Chongqing, ChinaDepartment of Infectious Diseases, Bishan Hospital of Chongqing Medical University (Bishan Hospital of Chongqing), Chongqing, ChinaPurposeThe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a crucial lipid marker associated with various cardiovascular diseases. However, its relationship with kidney injury, particularly albuminuria, remains poorly understood. This study aims to investigate the association between NHHR and macroalbuminuria in U.S. adultsPatients and methodsThis cross-sectional study utilized data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES). NHHR was calculated as (Total cholesterol - HDL cholesterol)/HDL cholesterol. Macroalbuminuria was defined by an albumin-creatinine ratio (ACR) >300 mg/g. Logistic regression, smoothed curve fitting, subgroup analyses, and sensitivity analysis were employed to assess the relationship between NHHR and macroalbuminuria.ResultsA total of 41,225 participants were included in the analysis. Higher NHHR was significantly associated with an increased likelihood of macroalbuminuria (OR = 1.34, 95% CI: 1.13–1.59, p=0.0007). Subgroup analysis revealed a stronger association in participants with BMI ≥30 kg/m2(OR = 1.89, 95% CI: 1.44–2.47, p<0.01). Sensitivity analysis revealed that the association remained robust even after excluding participants taking medications that affect lipid metabolism.ConclusionIn U.S. adults, an increased likelihood of incident NHHR levels of macroalbuminuria is positively associated and is more pronounced in those with a BMI ≥30kg/m2.https://www.frontiersin.org/articles/10.3389/fendo.2025.1503780/fullthe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratiomacroalbuminuriaNHANEScross-sectional studyACR - albumin to creatinine ratio |
| spellingShingle | Dongli Huang Yuan He Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 Frontiers in Endocrinology the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio macroalbuminuria NHANES cross-sectional study ACR - albumin to creatinine ratio |
| title | Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 |
| title_full | Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 |
| title_fullStr | Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 |
| title_full_unstemmed | Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 |
| title_short | Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 |
| title_sort | association between non high density lipoprotein cholesterol to high density lipoprotein cholesterol ratio and macroalbuminuria evidence from nhanes 1999 2018 |
| topic | the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio macroalbuminuria NHANES cross-sectional study ACR - albumin to creatinine ratio |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1503780/full |
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