High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome
Abstract Electroencephalographic source localisation (ESL) of interictal epileptiform discharges is a valuable tool for presurgical evaluation of pharmacoresistant focal epilepsy. Various forward models, inverse solutions algorithms, and software packages have been published. However, clinical valid...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-05740-z |
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| author | Bernd J. Vorderwülbecke Margherita Carboni Sebastien Tourbier Laurent Spinelli Denis Brunet Martin Seeber Christian M. Korff Shahan Momjian Maria Vargas Margitta Seeck Serge Vulliemoz Jonathan Wirsich |
| author_facet | Bernd J. Vorderwülbecke Margherita Carboni Sebastien Tourbier Laurent Spinelli Denis Brunet Martin Seeber Christian M. Korff Shahan Momjian Maria Vargas Margitta Seeck Serge Vulliemoz Jonathan Wirsich |
| author_sort | Bernd J. Vorderwülbecke |
| collection | DOAJ |
| description | Abstract Electroencephalographic source localisation (ESL) of interictal epileptiform discharges is a valuable tool for presurgical evaluation of pharmacoresistant focal epilepsy. Various forward models, inverse solutions algorithms, and software packages have been published. However, clinical validation studies are based on heterogenous end points and study cohorts. To allow comparison of different interictal ESL methods within one standardised dataset, we provide deidentified clinical data of 44 well-characterised patients with pharmacoresistant focal epilepsy and a first resective surgery, validated by 12-month postsurgical outcome. Thirty patients had favourable outcomes, including 28 with complete seizure freedom, indicating that the epileptogenic zone was correctly estimated. For each patient, pre-processed individual structural MRI, 257-channel EEG averages of homologous discharges, postsurgical structural neuroimaging, and detailed clinical and technical information are given. In patients with favourable outcomes, source maxima of averaged discharges were <10 mm remote from the resection in 67% and within a sublobe affected by the surgery in 83%. Future validation studies of new ESL approaches can be compared to this benchmark. |
| format | Article |
| id | doaj-art-e17261b87d4f43f88854445c0490fa1b |
| institution | Kabale University |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-e17261b87d4f43f88854445c0490fa1b2025-08-20T04:03:18ZengNature PortfolioScientific Data2052-44632025-08-011211810.1038/s41597-025-05740-zHigh-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical OutcomeBernd J. Vorderwülbecke0Margherita Carboni1Sebastien Tourbier2Laurent Spinelli3Denis Brunet4Martin Seeber5Christian M. Korff6Shahan Momjian7Maria Vargas8Margitta Seeck9Serge Vulliemoz10Jonathan Wirsich11EEG and Epilepsy Unit, Division of Neurology, Geneva University Hospitals and University of GenevaEEG and Epilepsy Unit, Division of Neurology, Geneva University Hospitals and University of GenevaConnectomics Lab, Department of Radiology, Lausanne University HospitalEEG and Epilepsy Unit, Division of Neurology, Geneva University Hospitals and University of GenevaFunctional Brain Mapping Lab, Department of Basic Neurosciences, University of Geneva, Campus BiotechFunctional Brain Mapping Lab, Department of Basic Neurosciences, University of Geneva, Campus BiotechNeuropediatrics Unit, Geneva University Hospitals and University of GenevaDepartment of Neurosurgery, Geneva University Hospitals and University of GenevaDepartment of Neuroradiology, Geneva University Hospitals and University of GenevaEEG and Epilepsy Unit, Division of Neurology, Geneva University Hospitals and University of GenevaEEG and Epilepsy Unit, Division of Neurology, Geneva University Hospitals and University of GenevaEEG and Epilepsy Unit, Division of Neurology, Geneva University Hospitals and University of GenevaAbstract Electroencephalographic source localisation (ESL) of interictal epileptiform discharges is a valuable tool for presurgical evaluation of pharmacoresistant focal epilepsy. Various forward models, inverse solutions algorithms, and software packages have been published. However, clinical validation studies are based on heterogenous end points and study cohorts. To allow comparison of different interictal ESL methods within one standardised dataset, we provide deidentified clinical data of 44 well-characterised patients with pharmacoresistant focal epilepsy and a first resective surgery, validated by 12-month postsurgical outcome. Thirty patients had favourable outcomes, including 28 with complete seizure freedom, indicating that the epileptogenic zone was correctly estimated. For each patient, pre-processed individual structural MRI, 257-channel EEG averages of homologous discharges, postsurgical structural neuroimaging, and detailed clinical and technical information are given. In patients with favourable outcomes, source maxima of averaged discharges were <10 mm remote from the resection in 67% and within a sublobe affected by the surgery in 83%. Future validation studies of new ESL approaches can be compared to this benchmark.https://doi.org/10.1038/s41597-025-05740-z |
| spellingShingle | Bernd J. Vorderwülbecke Margherita Carboni Sebastien Tourbier Laurent Spinelli Denis Brunet Martin Seeber Christian M. Korff Shahan Momjian Maria Vargas Margitta Seeck Serge Vulliemoz Jonathan Wirsich High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome Scientific Data |
| title | High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome |
| title_full | High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome |
| title_fullStr | High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome |
| title_full_unstemmed | High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome |
| title_short | High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome |
| title_sort | high density eeg source localisation of averaged interictal epileptic discharges validated by surgical outcome |
| url | https://doi.org/10.1038/s41597-025-05740-z |
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