The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis
Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/5037254 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568180745175040 |
|---|---|
| author | Yi-Zuo Song He-Yi You Zhe-Hui Zhu Zheng-De Wen Hui-Ying Xu Bi-Cheng Chen Zong-Jing Chen Qing-Ke Huang |
| author_facet | Yi-Zuo Song He-Yi You Zhe-Hui Zhu Zheng-De Wen Hui-Ying Xu Bi-Cheng Chen Zong-Jing Chen Qing-Ke Huang |
| author_sort | Yi-Zuo Song |
| collection | DOAJ |
| description | Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a precise estimation of the relationship between GNB3 polymorphisms and FD. Methods. We searched different databases including PubMed, EMBASE, CNKI, and the Ovid Library to gather eligible studies on GNB3 polymorphisms and FD. The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI). Results. We identified 12 studies with 1109 cases and 2853 controls for the analysis. We found no associations of GNB3 C825T polymorphism with FD in the overall population (T versus C, OR = 1.06, 95% CI: 0.96–1.18, P=0.26; TT versus CC + CT, OR = 1.16, 95% CI: 0.97–1.39, P=0.11; TT + CT versus CC, OR = 1.01, 95% CI: 0.77–1.31, P=0.96; TT versus CC, OR = 1.15, 95% CI: 0.93–1.44, P=0.20). Subgroup analyses by genotyping method indicated that the magnitude of association was strengthened for additive model (OR = 1.15, 95% CI: 1.07–2.24, P=0.02). Sensitivity analysis did not reveal significant associations under all models. Conclusions. This meta-analysis demonstrates that GNB3 C825T polymorphism may not be a risk factor for FD. |
| format | Article |
| id | doaj-art-e16cf667606d453b806838d13bee65f4 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e16cf667606d453b806838d13bee65f42025-02-03T00:59:40ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/50372545037254The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-AnalysisYi-Zuo Song0He-Yi You1Zhe-Hui Zhu2Zheng-De Wen3Hui-Ying Xu4Bi-Cheng Chen5Zong-Jing Chen6Qing-Ke Huang7Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaZhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaZhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaZhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaZhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaZhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaZhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaBackground. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a precise estimation of the relationship between GNB3 polymorphisms and FD. Methods. We searched different databases including PubMed, EMBASE, CNKI, and the Ovid Library to gather eligible studies on GNB3 polymorphisms and FD. The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI). Results. We identified 12 studies with 1109 cases and 2853 controls for the analysis. We found no associations of GNB3 C825T polymorphism with FD in the overall population (T versus C, OR = 1.06, 95% CI: 0.96–1.18, P=0.26; TT versus CC + CT, OR = 1.16, 95% CI: 0.97–1.39, P=0.11; TT + CT versus CC, OR = 1.01, 95% CI: 0.77–1.31, P=0.96; TT versus CC, OR = 1.15, 95% CI: 0.93–1.44, P=0.20). Subgroup analyses by genotyping method indicated that the magnitude of association was strengthened for additive model (OR = 1.15, 95% CI: 1.07–2.24, P=0.02). Sensitivity analysis did not reveal significant associations under all models. Conclusions. This meta-analysis demonstrates that GNB3 C825T polymorphism may not be a risk factor for FD.http://dx.doi.org/10.1155/2016/5037254 |
| spellingShingle | Yi-Zuo Song He-Yi You Zhe-Hui Zhu Zheng-De Wen Hui-Ying Xu Bi-Cheng Chen Zong-Jing Chen Qing-Ke Huang The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis Gastroenterology Research and Practice |
| title | The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis |
| title_full | The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis |
| title_fullStr | The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis |
| title_full_unstemmed | The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis |
| title_short | The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis |
| title_sort | c825t polymorphism of the g protein β3 gene as a risk factor for functional dyspepsia a meta analysis |
| url | http://dx.doi.org/10.1155/2016/5037254 |
| work_keys_str_mv | AT yizuosong thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT heyiyou thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT zhehuizhu thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT zhengdewen thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT huiyingxu thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT bichengchen thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT zongjingchen thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT qingkehuang thec825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT yizuosong c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT heyiyou c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT zhehuizhu c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT zhengdewen c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT huiyingxu c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT bichengchen c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT zongjingchen c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis AT qingkehuang c825tpolymorphismofthegproteinb3geneasariskfactorforfunctionaldyspepsiaametaanalysis |