Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats
Background Physical activity has profound benefits on health, especially in patients with cardiovascular and metabolic disease. Exercise training can reduce oxidative stress, improve renal function, and thus lower blood pressure. However, the effect of exercise training on angiotensin II type 1 rece...
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Taylor & Francis Group
2024-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2024.2323532 |
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| author | Jingjing Lu Zhengsheng Li Yinan Yang Fangning Wei |
| author_facet | Jingjing Lu Zhengsheng Li Yinan Yang Fangning Wei |
| author_sort | Jingjing Lu |
| collection | DOAJ |
| description | Background Physical activity has profound benefits on health, especially in patients with cardiovascular and metabolic disease. Exercise training can reduce oxidative stress, improve renal function, and thus lower blood pressure. However, the effect of exercise training on angiotensin II type 1 receptors (AT1R) and endothelin subtype B receptors (ETBR)-mediated diuresis and natriuresis in obese Zucker rats is unclear.Methods Lean and obese Zucker rats were exercised or placed on a nonmoving treadmill for 8 weeks. Blood pressure was measured by tail-cuff plethysmography, and functions of AT1R and ETBR in the kidney were measured by natriuresis, respectively.Results Our data showed that exercise training improved glucose and lipid metabolism, renal function and sodium excretion in obese Zucker rats, accompanied by decreased oxidative stress and GRK4 expression in obese Zucker rats. Moreover, exercise training reduced the Candesartan-induced an increase in diuresis and natriuresis and increased ETBR agonists (BQ3020)-mediated diuresis and natriuresis in obese Zucker rats, which were associated with decreased renal AT1R expression and ETBR phosphorylation levels.Conclusions The results demonstrate that exercise training lowers blood pressure via improving renal AT1R and ETBR function through modulating GRK4 expression in Obese Zucker Rats and provides potentially effective targets for obesity-related hypertension. |
| format | Article |
| id | doaj-art-e16ca839cc164ce08ee71f996a130bd8 |
| institution | OA Journals |
| issn | 1064-1963 1525-6006 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj-art-e16ca839cc164ce08ee71f996a130bd82025-08-20T02:35:50ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062024-12-0146110.1080/10641963.2024.2323532Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker ratsJingjing Lu0Zhengsheng Li1Yinan Yang2Fangning Wei3The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Nephrology, The Secondary Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaDepartment of Nephrology, The Secondary Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaBackground Physical activity has profound benefits on health, especially in patients with cardiovascular and metabolic disease. Exercise training can reduce oxidative stress, improve renal function, and thus lower blood pressure. However, the effect of exercise training on angiotensin II type 1 receptors (AT1R) and endothelin subtype B receptors (ETBR)-mediated diuresis and natriuresis in obese Zucker rats is unclear.Methods Lean and obese Zucker rats were exercised or placed on a nonmoving treadmill for 8 weeks. Blood pressure was measured by tail-cuff plethysmography, and functions of AT1R and ETBR in the kidney were measured by natriuresis, respectively.Results Our data showed that exercise training improved glucose and lipid metabolism, renal function and sodium excretion in obese Zucker rats, accompanied by decreased oxidative stress and GRK4 expression in obese Zucker rats. Moreover, exercise training reduced the Candesartan-induced an increase in diuresis and natriuresis and increased ETBR agonists (BQ3020)-mediated diuresis and natriuresis in obese Zucker rats, which were associated with decreased renal AT1R expression and ETBR phosphorylation levels.Conclusions The results demonstrate that exercise training lowers blood pressure via improving renal AT1R and ETBR function through modulating GRK4 expression in Obese Zucker Rats and provides potentially effective targets for obesity-related hypertension.https://www.tandfonline.com/doi/10.1080/10641963.2024.2323532Exerciseobesityhypertensionangiotensin II type 1 receptorendothelin subtype B receptorGRK4 |
| spellingShingle | Jingjing Lu Zhengsheng Li Yinan Yang Fangning Wei Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats Clinical and Experimental Hypertension Exercise obesity hypertension angiotensin II type 1 receptor endothelin subtype B receptor GRK4 |
| title | Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats |
| title_full | Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats |
| title_fullStr | Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats |
| title_full_unstemmed | Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats |
| title_short | Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats |
| title_sort | chronic exercise improves renal at1 and etb receptor functions via modulating grk4 expression in obese zucker rats |
| topic | Exercise obesity hypertension angiotensin II type 1 receptor endothelin subtype B receptor GRK4 |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2024.2323532 |
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