Modern modes of chronic hepatitis C treatment
The aim of review. To highlight up-to-date modes of chronic hepatitis C treatment.Original positions. Nowadays conventional «gold standard» treatment of chronic HCV-infection is antiviral therapy by pegilated interferon and ribavirin combination. Recently principles of antiviral treatment were serio...
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| Format: | Article |
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Gastro LLC
2012-02-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1260 |
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| author | V. T. Ivashkin M. V. Mayevskaya M. A. Morozova Ye. O. Lyusina |
| author_facet | V. T. Ivashkin M. V. Mayevskaya M. A. Morozova Ye. O. Lyusina |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | The aim of review. To highlight up-to-date modes of chronic hepatitis C treatment.Original positions. Nowadays conventional «gold standard» treatment of chronic HCV-infection is antiviral therapy by pegilated interferon and ribavirin combination. Recently principles of antiviral treatment were seriously reconsidered, that inevitably leads to sophistication of therapeutic algorithms. So, modification of treatment mode according to virologic response is rational today. In near-term prospect addition of the third agent — protease inhibitor to the standard combination treatment mode will become possible soon. Published results of large investigations prove significantly higher efficacy of triple therapeutic mode in patients with the 1-st hepatitis C virus genotype, that opens new wide perspectives in treatment of these patients.Conclusion. Recently individual approach to treatment of patients with chronic HCV-infection becomes more actual. In particular, the algorithm of therapeutic mode modification according to virologic response to treatment at the specific patient is developed. In some cases it enables reduction of treatment terms, decrease of cost and increase of patient’s compliance. Moreover, in the close perspective new antiviral agents - protease inhibitors will appear at the market, that allows to increase antiviral treatment efficacy in patients with the 1-st hepatitis C virus genotype. |
| format | Article |
| id | doaj-art-e16be070d7f94c4284bc076d16372ce2 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2012-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-e16be070d7f94c4284bc076d16372ce22025-02-10T16:14:31ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732012-02-012213644841Modern modes of chronic hepatitis C treatmentV. T. Ivashkin0M. V. Mayevskaya1M. A. Morozova2Ye. O. Lyusina3ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФThe aim of review. To highlight up-to-date modes of chronic hepatitis C treatment.Original positions. Nowadays conventional «gold standard» treatment of chronic HCV-infection is antiviral therapy by pegilated interferon and ribavirin combination. Recently principles of antiviral treatment were seriously reconsidered, that inevitably leads to sophistication of therapeutic algorithms. So, modification of treatment mode according to virologic response is rational today. In near-term prospect addition of the third agent — protease inhibitor to the standard combination treatment mode will become possible soon. Published results of large investigations prove significantly higher efficacy of triple therapeutic mode in patients with the 1-st hepatitis C virus genotype, that opens new wide perspectives in treatment of these patients.Conclusion. Recently individual approach to treatment of patients with chronic HCV-infection becomes more actual. In particular, the algorithm of therapeutic mode modification according to virologic response to treatment at the specific patient is developed. In some cases it enables reduction of treatment terms, decrease of cost and increase of patient’s compliance. Moreover, in the close perspective new antiviral agents - protease inhibitors will appear at the market, that allows to increase antiviral treatment efficacy in patients with the 1-st hepatitis C virus genotype.https://www.gastro-j.ru/jour/article/view/1260hepatitis cantiviral therapyvirologic responseprotease inhibitorstelaprevirboceprevir |
| spellingShingle | V. T. Ivashkin M. V. Mayevskaya M. A. Morozova Ye. O. Lyusina Modern modes of chronic hepatitis C treatment Российский журнал гастроэнтерологии, гепатологии, колопроктологии hepatitis c antiviral therapy virologic response protease inhibitors telaprevir boceprevir |
| title | Modern modes of chronic hepatitis C treatment |
| title_full | Modern modes of chronic hepatitis C treatment |
| title_fullStr | Modern modes of chronic hepatitis C treatment |
| title_full_unstemmed | Modern modes of chronic hepatitis C treatment |
| title_short | Modern modes of chronic hepatitis C treatment |
| title_sort | modern modes of chronic hepatitis c treatment |
| topic | hepatitis c antiviral therapy virologic response protease inhibitors telaprevir boceprevir |
| url | https://www.gastro-j.ru/jour/article/view/1260 |
| work_keys_str_mv | AT vtivashkin modernmodesofchronichepatitisctreatment AT mvmayevskaya modernmodesofchronichepatitisctreatment AT mamorozova modernmodesofchronichepatitisctreatment AT yeolyusina modernmodesofchronichepatitisctreatment |