Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation to the dysfunction of the vascular reserve, is the paradise lost?

Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation to the dysfunction of the vascular reserve, is the paradise lost?

Abstract Microvascular dysfunction is considered one of the main pathogenetic pathways in systemic sclerosis (SSc), and endothelial cells plays a pivotal role even in the early phases of the disease. Endothelial dysfunction results in an early incapacity to adapt the vascular tone and the blood flow...

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Bibliographic Details
Main Authors: Giulia Bandini, Silvia Bellando Randone, Mirko Manetti, Lorenzo Dagna, Marco Matucci Cerinic, Alberto Moggi Pignone
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Vascular reserve
Endotheliopathy
Endothelial dysfunction
Online Access:https://doi.org/10.1186/s13075-025-03568-x
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https://doi.org/10.1186/s13075-025-03568-x

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