CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model

CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model

Abstract Background CD24 plays a crucial role not only in promoting tumor progression and metastasis but also in modulating macrophage-mediated anti-tumor immunity. However, its impact on the immune landscape of the tumor microenvironment (TME) remains unexplored. Here, we investigated the role of C...

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Bibliographic Details
Main Authors: Shih-Hsuan Chan, Chin-Yu Lin, Hsuan-Jung Tseng, Lu-Hai Wang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Biomedical Science
Subjects:
CD24a
CRISPR/Cas9 knockout
Triple-negative breast cancer
Tumor microenvironment
Macrophages
CD8+ T cells
Online Access:https://doi.org/10.1186/s12929-025-01165-3
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