Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy
Aim of investigation. To outline predictive model for unfavorable course of ulcerative colitis (UC).Material and methods. Overall 232 patients with UC were included in original study, 84 of them had favourable and 148 – unfavorable course of disease.Results. Prognostic system for various variants of...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2012-06-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1301 |
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| author | A. Yu. Baranovsky E. A. Kondrashina A. G. Kharitonov |
| author_facet | A. Yu. Baranovsky E. A. Kondrashina A. G. Kharitonov |
| author_sort | A. Yu. Baranovsky |
| collection | DOAJ |
| description | Aim of investigation. To outline predictive model for unfavorable course of ulcerative colitis (UC).Material and methods. Overall 232 patients with UC were included in original study, 84 of them had favourable and 148 – unfavorable course of disease.Results. Prognostic system for various variants of course of UC and its complications, 27 most significant clinical signs of disease based on differentiated clinical and statistical evaluation was submitted. To define indications for «top down» therapy with application of TNF-α blockers clinically approved algorithm of prognostic decisions for development of favorable (uncomplicated, rarely relapsing) and unfavorable (frequently relapsing, continuous, steroiddependent) variants of disease, and its complications was stated. Basing on high scores of sensitivity (accuracy) and specificity of prognosis, that were received, data proving potential of indications for early anticytokine treatment by infliximab to avoid unfavorable course and complications of ulcerative colitis are presented. |
| format | Article |
| id | doaj-art-e16325ba2cb44edf8f031bc14ca4b44b |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2012-06-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-e16325ba2cb44edf8f031bc14ca4b44b2025-02-10T16:14:32ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732012-06-012236369873Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapyA. Yu. Baranovsky0E. A. Kondrashina1A. G. Kharitonov2State educational government-financed institution of higher professional education Mechnikov North-Western State medical UniversityState educational government-financed institution of higher professional education Mechnikov North-Western State medical UniversityState educational government-financed institution of higher professional education Mechnikov North-Western State medical UniversityAim of investigation. To outline predictive model for unfavorable course of ulcerative colitis (UC).Material and methods. Overall 232 patients with UC were included in original study, 84 of them had favourable and 148 – unfavorable course of disease.Results. Prognostic system for various variants of course of UC and its complications, 27 most significant clinical signs of disease based on differentiated clinical and statistical evaluation was submitted. To define indications for «top down» therapy with application of TNF-α blockers clinically approved algorithm of prognostic decisions for development of favorable (uncomplicated, rarely relapsing) and unfavorable (frequently relapsing, continuous, steroiddependent) variants of disease, and its complications was stated. Basing on high scores of sensitivity (accuracy) and specificity of prognosis, that were received, data proving potential of indications for early anticytokine treatment by infliximab to avoid unfavorable course and complications of ulcerative colitis are presented.https://www.gastro-j.ru/jour/article/view/1301ulcerative colitisprognosisanticytokine therapy |
| spellingShingle | A. Yu. Baranovsky E. A. Kondrashina A. G. Kharitonov Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy Российский журнал гастроэнтерологии, гепатологии, колопроктологии ulcerative colitis prognosis anticytokine therapy |
| title | Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy |
| title_full | Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy |
| title_fullStr | Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy |
| title_full_unstemmed | Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy |
| title_short | Prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy |
| title_sort | prognosis of unfavorable course of ulcerative colitis as indication for anticytokine therapy |
| topic | ulcerative colitis prognosis anticytokine therapy |
| url | https://www.gastro-j.ru/jour/article/view/1301 |
| work_keys_str_mv | AT ayubaranovsky prognosisofunfavorablecourseofulcerativecolitisasindicationforanticytokinetherapy AT eakondrashina prognosisofunfavorablecourseofulcerativecolitisasindicationforanticytokinetherapy AT agkharitonov prognosisofunfavorablecourseofulcerativecolitisasindicationforanticytokinetherapy |