The PE/PPE family proteins of Mycobacterium tuberculosis: evolution, function, and prospects for tuberculosis control

The PE/PPE family proteins of Mycobacterium tuberculosis: evolution, function, and prospects for tuberculosis control

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global health threat, exacerbated by drug resistance and inadequate vaccine efficacy. The PE/PPE protein family, unique to mycobacteria, constitutes ~10% of the Mtb genome and plays critical roles in bacterial physiolog...

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Bibliographic Details
Main Authors: Zhijing Zhang, Le Dong, Xin Li, Taibing Deng, Qinglan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
PE/PPE
evolution
outer membrane
porin
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1606311/full
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