Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures

Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures

ABSTRACT Mycobacterium tuberculosis (Mtb) exhibits an impressive ability to adapt to rapidly changing environments, despite its genome’s apparent stability. Recently, phase variation through indel formation in homopolymeric tracts (HT) has emerged as a potentially important mechanism promoting adapt...

Full description

Saved in:
Bibliographic Details
Main Authors: Michael J. Luna, Peter O. Oluoch, Jiazheng Miao, Peter Culviner, Kadamba Papavinasasundaram, Eleni Jaecklein, Scarlet S. Shell, Thomas R. Ioerger, Sarah M. Fortune, Maha R. Farhat, Christopher M. Sassetti
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mBio
Subjects:
tuberculosis
bacterial genetics
phase variation
Online Access:https://journals.asm.org/doi/10.1128/mbio.03762-24
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://journals.asm.org/doi/10.1128/mbio.03762-24

Similar Items