Synthesis of thiosemicarbazone Schiff base derivatives as anti-leishmanial agents and molecular dynamics simulations insights

Synthesis of thiosemicarbazone Schiff base derivatives as anti-leishmanial agents and molecular dynamics simulations insights

Abstract Leishmaniasis is one of the infectious diseases caused by protozoa and is considered the second most significant parasitic disease after malaria. In this research, thiosemicarbazone Schiff base derivatives were synthesized via a one-pot, two-step, three-component reaction. Then, the effecti...

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Bibliographic Details
Main Authors: Soheila Molaei, Jafar Abbasi Shiran, Neda Shakour, Majid Baradaran, Zahra Malihi, Mohammad Reza Rahimi, Yasamin Abedini Zal, Saghi Sepehri
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Promastigote
Amastigote
Tropical disease
Apoptosis
Hydrazine-1-carbothioamide
Online Access:https://doi.org/10.1038/s41598-025-10545-6
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https://doi.org/10.1038/s41598-025-10545-6

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