Application of human cardiac organoids in cardiovascular disease research
With the progression of cardiovascular disease (CVD) treatment technologies, conventional animal models face limitations in clinical translation due to interspecies variations. Recently, human cardiac organoids (hCOs) have emerged as an innovative platform for CVD research. This review provides a co...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1564889/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850062246134153216 |
|---|---|
| author | Hongyan Zhang Hongyan Zhang Peng Qu Jun Liu Panke Cheng Panke Cheng Qian Lei Qian Lei |
| author_facet | Hongyan Zhang Hongyan Zhang Peng Qu Jun Liu Panke Cheng Panke Cheng Qian Lei Qian Lei |
| author_sort | Hongyan Zhang |
| collection | DOAJ |
| description | With the progression of cardiovascular disease (CVD) treatment technologies, conventional animal models face limitations in clinical translation due to interspecies variations. Recently, human cardiac organoids (hCOs) have emerged as an innovative platform for CVD research. This review provides a comprehensive overview of the definition, characteristics, classifications, application and development of hCOs. Furthermore, this review examines the application of hCOs in models of myocardial infarction, heart failure, arrhythmias, and congenital heart diseases, highlighting their significance in replicating disease mechanisms and pathophysiological processes. It also explores their potential utility in drug screening and the development of therapeutic strategies. Although challenges persist regarding technical complexity and the standardization of models, the integration of multi-omics and artificial intelligence (AI) technologies offers a promising avenue for the clinical translation of hCOs. |
| format | Article |
| id | doaj-art-e15b472e37194423b1ae1e74edaf8df0 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-e15b472e37194423b1ae1e74edaf8df02025-08-20T02:49:59ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.15648891564889Application of human cardiac organoids in cardiovascular disease researchHongyan Zhang0Hongyan Zhang1Peng Qu2Jun Liu3Panke Cheng4Panke Cheng5Qian Lei6Qian Lei7Department of Anesthesiology, Chengdu Wenjiang District People’s Hospital, Chengdu, ChinaDepartment of Anesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaInstitute of Cardiovascular Diseases and Department of Cardiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaInstitute of Cardiovascular Diseases and Department of Cardiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaInstitute of Cardiovascular Diseases and Department of Cardiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaUltrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Chengdu, ChinaDepartment of Anesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaUltrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Chengdu, ChinaWith the progression of cardiovascular disease (CVD) treatment technologies, conventional animal models face limitations in clinical translation due to interspecies variations. Recently, human cardiac organoids (hCOs) have emerged as an innovative platform for CVD research. This review provides a comprehensive overview of the definition, characteristics, classifications, application and development of hCOs. Furthermore, this review examines the application of hCOs in models of myocardial infarction, heart failure, arrhythmias, and congenital heart diseases, highlighting their significance in replicating disease mechanisms and pathophysiological processes. It also explores their potential utility in drug screening and the development of therapeutic strategies. Although challenges persist regarding technical complexity and the standardization of models, the integration of multi-omics and artificial intelligence (AI) technologies offers a promising avenue for the clinical translation of hCOs.https://www.frontiersin.org/articles/10.3389/fcell.2025.1564889/fullhuman cardiac organoidscardiovascular diseaseclinical translationdisease modelsdrug screening |
| spellingShingle | Hongyan Zhang Hongyan Zhang Peng Qu Jun Liu Panke Cheng Panke Cheng Qian Lei Qian Lei Application of human cardiac organoids in cardiovascular disease research Frontiers in Cell and Developmental Biology human cardiac organoids cardiovascular disease clinical translation disease models drug screening |
| title | Application of human cardiac organoids in cardiovascular disease research |
| title_full | Application of human cardiac organoids in cardiovascular disease research |
| title_fullStr | Application of human cardiac organoids in cardiovascular disease research |
| title_full_unstemmed | Application of human cardiac organoids in cardiovascular disease research |
| title_short | Application of human cardiac organoids in cardiovascular disease research |
| title_sort | application of human cardiac organoids in cardiovascular disease research |
| topic | human cardiac organoids cardiovascular disease clinical translation disease models drug screening |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1564889/full |
| work_keys_str_mv | AT hongyanzhang applicationofhumancardiacorganoidsincardiovasculardiseaseresearch AT hongyanzhang applicationofhumancardiacorganoidsincardiovasculardiseaseresearch AT pengqu applicationofhumancardiacorganoidsincardiovasculardiseaseresearch AT junliu applicationofhumancardiacorganoidsincardiovasculardiseaseresearch AT pankecheng applicationofhumancardiacorganoidsincardiovasculardiseaseresearch AT pankecheng applicationofhumancardiacorganoidsincardiovasculardiseaseresearch AT qianlei applicationofhumancardiacorganoidsincardiovasculardiseaseresearch AT qianlei applicationofhumancardiacorganoidsincardiovasculardiseaseresearch |