Homoharringtonine: mechanisms, clinical applications and research progress
Homoharringtonine is a natural alkaloid with significant pharmacological potential that has demonstrated promising efficacy in the treatment of hematological malignancies in recent years. This article systematically reviews the pharmacological mechanisms of Homoharringtonine, focusing on its key rol...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1522273/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582062934065152 |
|---|---|
| author | Wen Wang Lan He Lan He Ting Lin Ting Lin Ting Lin Fulan Xiang Yibin Wu Fangliang Zhou Fangliang Zhou Fangliang Zhou Yingchun He Yingchun He Yingchun He |
| author_facet | Wen Wang Lan He Lan He Ting Lin Ting Lin Ting Lin Fulan Xiang Yibin Wu Fangliang Zhou Fangliang Zhou Fangliang Zhou Yingchun He Yingchun He Yingchun He |
| author_sort | Wen Wang |
| collection | DOAJ |
| description | Homoharringtonine is a natural alkaloid with significant pharmacological potential that has demonstrated promising efficacy in the treatment of hematological malignancies in recent years. This article systematically reviews the pharmacological mechanisms of Homoharringtonine, focusing on its key roles in inducing apoptosis, inhibiting cell cycle progression, and reducing cell migration and invasion. Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, and anti-fibrotic properties, with recent studies also revealing its potential neuroprotective functions. In clinical trials, Homoharringtonine has demonstrated promising efficacy in the treatment of hematological malignancies, particularly in various types such as acute myeloid leukemia and chronic myeloid leukemia. Despite the significant antitumor effects observed in clinical applications, its low bioavailability and potential side effects remain major challenges that limit its widespread use. This article details the latest research advancements aimed at enhancing the bioavailability of Homoharringtonine, including various drug delivery systems such as nanoparticles and liposomes, as well as chemical modification strategies. These approaches not only improve HHT’s bioavailability in vivo but also enhance its targeting ability while reducing toxicity to normal cells. Furthermore, the combination of HHT with other drugs presents broader prospects for clinical treatment. By exploring the diverse pharmacological activities of Homoharringtonine in depth, this article aims to provide a foundation for developing novel therapeutic approaches based on natural products, thereby advancing HHT’s application research in cancer treatment and other fields. |
| format | Article |
| id | doaj-art-e15a3b6249af4da3bfa72a56132eb0f9 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-e15a3b6249af4da3bfa72a56132eb0f92025-01-30T06:22:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15222731522273Homoharringtonine: mechanisms, clinical applications and research progressWen Wang0Lan He1Lan He2Ting Lin3Ting Lin4Ting Lin5Fulan Xiang6Yibin Wu7Fangliang Zhou8Fangliang Zhou9Fangliang Zhou10Yingchun He11Yingchun He12Yingchun He13Graduate School, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaGraduate School, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaGraduate School, Hunan University of Chinese Medicine, Changsha, ChinaGraduate School, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaMedical School, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaMedical School, Hunan University of Chinese Medicine, Changsha, ChinaHomoharringtonine is a natural alkaloid with significant pharmacological potential that has demonstrated promising efficacy in the treatment of hematological malignancies in recent years. This article systematically reviews the pharmacological mechanisms of Homoharringtonine, focusing on its key roles in inducing apoptosis, inhibiting cell cycle progression, and reducing cell migration and invasion. Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, and anti-fibrotic properties, with recent studies also revealing its potential neuroprotective functions. In clinical trials, Homoharringtonine has demonstrated promising efficacy in the treatment of hematological malignancies, particularly in various types such as acute myeloid leukemia and chronic myeloid leukemia. Despite the significant antitumor effects observed in clinical applications, its low bioavailability and potential side effects remain major challenges that limit its widespread use. This article details the latest research advancements aimed at enhancing the bioavailability of Homoharringtonine, including various drug delivery systems such as nanoparticles and liposomes, as well as chemical modification strategies. These approaches not only improve HHT’s bioavailability in vivo but also enhance its targeting ability while reducing toxicity to normal cells. Furthermore, the combination of HHT with other drugs presents broader prospects for clinical treatment. By exploring the diverse pharmacological activities of Homoharringtonine in depth, this article aims to provide a foundation for developing novel therapeutic approaches based on natural products, thereby advancing HHT’s application research in cancer treatment and other fields.https://www.frontiersin.org/articles/10.3389/fonc.2025.1522273/fullhomoharringtoninehematological disordersantitumor activitypharmacological mechanismsclinical applicationscancer treatment |
| spellingShingle | Wen Wang Lan He Lan He Ting Lin Ting Lin Ting Lin Fulan Xiang Yibin Wu Fangliang Zhou Fangliang Zhou Fangliang Zhou Yingchun He Yingchun He Yingchun He Homoharringtonine: mechanisms, clinical applications and research progress Frontiers in Oncology homoharringtonine hematological disorders antitumor activity pharmacological mechanisms clinical applications cancer treatment |
| title | Homoharringtonine: mechanisms, clinical applications and research progress |
| title_full | Homoharringtonine: mechanisms, clinical applications and research progress |
| title_fullStr | Homoharringtonine: mechanisms, clinical applications and research progress |
| title_full_unstemmed | Homoharringtonine: mechanisms, clinical applications and research progress |
| title_short | Homoharringtonine: mechanisms, clinical applications and research progress |
| title_sort | homoharringtonine mechanisms clinical applications and research progress |
| topic | homoharringtonine hematological disorders antitumor activity pharmacological mechanisms clinical applications cancer treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1522273/full |
| work_keys_str_mv | AT wenwang homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT lanhe homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT lanhe homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT tinglin homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT tinglin homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT tinglin homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT fulanxiang homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT yibinwu homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT fangliangzhou homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT fangliangzhou homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT fangliangzhou homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT yingchunhe homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT yingchunhe homoharringtoninemechanismsclinicalapplicationsandresearchprogress AT yingchunhe homoharringtoninemechanismsclinicalapplicationsandresearchprogress |