Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application
Doxorubicin is a commonly used antitumor drug for the treatment of various cancers. However, its clinical application is greatly restricted by its severe cardiotoxicity. At present, doxorubicin-induced cardiotoxicity is categorized into acute and chronic forms, depending on the dosage and duration o...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Forensic Medicine
2025-04-01
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| Series: | Fayixue Zazhi |
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| Online Access: | http://www.fyxzz.cn/CN/10.12116/j.issn.1004-5619.2024.440404 |
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| author | ZHANG Shuai XU Hong-fei ZHANG Zhi-xiang WANG Ying ZHU Shao-hua |
| author_facet | ZHANG Shuai XU Hong-fei ZHANG Zhi-xiang WANG Ying ZHU Shao-hua |
| author_sort | ZHANG Shuai |
| collection | DOAJ |
| description | Doxorubicin is a commonly used antitumor drug for the treatment of various cancers. However, its clinical application is greatly restricted by its severe cardiotoxicity. At present, doxorubicin-induced cardiotoxicity is categorized into acute and chronic forms, depending on the dosage and duration of exposure, which may eventually lead to the occurrence of heart failure. The pathogenesis of doxorubicin cardiotoxicity is associated with oxidative stress, mitochondrial damage, calcium overload, dysregulation of autophagy, and apoptosis. In forensic medical practice, cases of poisoning or even cardiac death caused by doxorubicin showed no obvious changes in cardiac morphology through routine forensic pathological examinations. The paper aims to summarize the research on the mechanisms of action of doxorubicin-induced cardiotoxicity in recent years, analyze and discuss the possible pathways of cardiomyocyte injury caused by doxorubicin, and provide references for research on the mechanisms of doxorubicin-induced cardiotoxicity and forensic application. |
| format | Article |
| id | doaj-art-e15a36b6a8bb4929a60a73171774a4ce |
| institution | Kabale University |
| issn | 1004-5619 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Editorial Office of Journal of Forensic Medicine |
| record_format | Article |
| series | Fayixue Zazhi |
| spelling | doaj-art-e15a36b6a8bb4929a60a73171774a4ce2025-08-20T03:41:40ZzhoEditorial Office of Journal of Forensic MedicineFayixue Zazhi1004-56192025-04-0141212012610.12116/j.issn.1004-5619.2024.4404041004-5619（2025）02-0120-07Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic ApplicationZHANG Shuai0XU Hong-fei1ZHANG Zhi-xiang2WANG Ying3ZHU Shao-hua4Department of Forensic Medicine, School of Basic Medical Sciences, Soochow University, Suzhou 215123, Jiang-su Province, ChinaDepartment of Forensic Medicine, School of Basic Medical Sciences, Soochow University, Suzhou 215123, Jiang-su Province, ChinaDepartment of Forensic Medicine, School of Basic Medical Sciences, Soochow University, Suzhou 215123, Jiang-su Province, ChinaDepartment of Forensic Medicine, School of Basic Medical Sciences, Soochow University, Suzhou 215123, Jiang-su Province, ChinaDepartment of Forensic Medicine, School of Basic Medical Sciences, Soochow University, Suzhou 215123, Jiang-su Province, ChinaDoxorubicin is a commonly used antitumor drug for the treatment of various cancers. However, its clinical application is greatly restricted by its severe cardiotoxicity. At present, doxorubicin-induced cardiotoxicity is categorized into acute and chronic forms, depending on the dosage and duration of exposure, which may eventually lead to the occurrence of heart failure. The pathogenesis of doxorubicin cardiotoxicity is associated with oxidative stress, mitochondrial damage, calcium overload, dysregulation of autophagy, and apoptosis. In forensic medical practice, cases of poisoning or even cardiac death caused by doxorubicin showed no obvious changes in cardiac morphology through routine forensic pathological examinations. The paper aims to summarize the research on the mechanisms of action of doxorubicin-induced cardiotoxicity in recent years, analyze and discuss the possible pathways of cardiomyocyte injury caused by doxorubicin, and provide references for research on the mechanisms of doxorubicin-induced cardiotoxicity and forensic application.http://www.fyxzz.cn/CN/10.12116/j.issn.1004-5619.2024.440404forensic pathologyforensic toxicologydoxorubicincardiotoxicitymechanism of drug actionreview |
| spellingShingle | ZHANG Shuai XU Hong-fei ZHANG Zhi-xiang WANG Ying ZHU Shao-hua Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application Fayixue Zazhi forensic pathology forensic toxicology doxorubicin cardiotoxicity mechanism of drug action review |
| title | Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application |
| title_full | Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application |
| title_fullStr | Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application |
| title_full_unstemmed | Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application |
| title_short | Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Application |
| title_sort | research on doxorubicin induced cardiotoxicity mechanism and its forensic application |
| topic | forensic pathology forensic toxicology doxorubicin cardiotoxicity mechanism of drug action review |
| url | http://www.fyxzz.cn/CN/10.12116/j.issn.1004-5619.2024.440404 |
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