A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia
Abstract Background Major depressive disorder (MDD) and schizophrenia (SCH) are common and severe mental disorders that are mainly diagnosed depending on the subjective identification by psychiatrists. Finding potential objective biomarkers that can distinguish these two diseases is still meaningful...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-024-06277-y |
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| author | Huan Yu Rui Li Xue-jun Liang Wen-Mao Yang Lin Guo Ling Liu Qing-rong R. Tan Zheng-wu Peng |
| author_facet | Huan Yu Rui Li Xue-jun Liang Wen-Mao Yang Lin Guo Ling Liu Qing-rong R. Tan Zheng-wu Peng |
| author_sort | Huan Yu |
| collection | DOAJ |
| description | Abstract Background Major depressive disorder (MDD) and schizophrenia (SCH) are common and severe mental disorders that are mainly diagnosed depending on the subjective identification by psychiatrists. Finding potential objective biomarkers that can distinguish these two diseases is still meaningful. Methods In the present study, we investigate the differences in plasma inflammatory cytokines and short-chain fatty acids (SCFAs) among patients with MDD (n = 24) and SCH (n = 24), and gender- and age-matched healthy controls (HC, n = 27) and identify potential plasma biomarkers. Results We found that the concentrations of pro-inflammatory cytokines were increased, whereas the anti-inflammatory cytokines were decreased in both MDD and SCH. Meanwhile, except for an increase in 4-Methylvaleric acid, other SCFAs with statistical differences were reduced in both MDD and SCH. Moreover, potential biomarker panels were developed that can effectively discriminate MDD from HC (AUC = 0.997), SCH from HC (AUC = 0.999), and from each other (MDD from SCH, AUC = 0.983). Conclusions These data suggest that alterations in plasma cytokines and SCFAs might be one of the potential features for distinguishing MDD and SCH. Trial registration Chinese Clinical Trial Registry: ChiCTR2100051243, registration date: 2021/09/16. |
| format | Article |
| id | doaj-art-e155d9bae9ec47959db2e2a74a401801 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-e155d9bae9ec47959db2e2a74a4018012024-11-24T12:38:03ZengBMCBMC Psychiatry1471-244X2024-11-0124111210.1186/s12888-024-06277-yA cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophreniaHuan Yu0Rui Li1Xue-jun Liang2Wen-Mao Yang3Lin Guo4Ling Liu5Qing-rong R. Tan6Zheng-wu Peng7Department of Psychiatry, Chang’an HospitalDepartment of Psychiatry, Chang’an HospitalDepartment of Psychiatry, Chang’an HospitalDepartment of Psychiatry, Chang’an HospitalDepartment of Psychiatry, Chang’an HospitalMilitary Medical Innovation Center, Air Force Medical UniversityDepartment of Psychiatry, Chang’an HospitalDepartment of Psychiatry, Chang’an HospitalAbstract Background Major depressive disorder (MDD) and schizophrenia (SCH) are common and severe mental disorders that are mainly diagnosed depending on the subjective identification by psychiatrists. Finding potential objective biomarkers that can distinguish these two diseases is still meaningful. Methods In the present study, we investigate the differences in plasma inflammatory cytokines and short-chain fatty acids (SCFAs) among patients with MDD (n = 24) and SCH (n = 24), and gender- and age-matched healthy controls (HC, n = 27) and identify potential plasma biomarkers. Results We found that the concentrations of pro-inflammatory cytokines were increased, whereas the anti-inflammatory cytokines were decreased in both MDD and SCH. Meanwhile, except for an increase in 4-Methylvaleric acid, other SCFAs with statistical differences were reduced in both MDD and SCH. Moreover, potential biomarker panels were developed that can effectively discriminate MDD from HC (AUC = 0.997), SCH from HC (AUC = 0.999), and from each other (MDD from SCH, AUC = 0.983). Conclusions These data suggest that alterations in plasma cytokines and SCFAs might be one of the potential features for distinguishing MDD and SCH. Trial registration Chinese Clinical Trial Registry: ChiCTR2100051243, registration date: 2021/09/16.https://doi.org/10.1186/s12888-024-06277-yInflammatory cytokinesShort-chain fatty acidsSchizophreniaDepression |
| spellingShingle | Huan Yu Rui Li Xue-jun Liang Wen-Mao Yang Lin Guo Ling Liu Qing-rong R. Tan Zheng-wu Peng A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia BMC Psychiatry Inflammatory cytokines Short-chain fatty acids Schizophrenia Depression |
| title | A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia |
| title_full | A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia |
| title_fullStr | A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia |
| title_full_unstemmed | A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia |
| title_short | A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia |
| title_sort | cross section study of the comparison of plasma inflammatory cytokines and short chain fatty acid in patients with depression and schizophrenia |
| topic | Inflammatory cytokines Short-chain fatty acids Schizophrenia Depression |
| url | https://doi.org/10.1186/s12888-024-06277-y |
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