New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc
The mainstream view on the neurobiological mechanisms underlying memory formation states that memory traces reside on the network of cells activated during initial acquisition that becomes active again upon retrieval (reactivation). These activation and reactivation processes have been called “conju...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/184083 |
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| author | Jean-Pascal Morin Kioko Guzmán-Ramos Federico Bermudez-Rattoni |
| author_facet | Jean-Pascal Morin Kioko Guzmán-Ramos Federico Bermudez-Rattoni |
| author_sort | Jean-Pascal Morin |
| collection | DOAJ |
| description | The mainstream view on the neurobiological mechanisms underlying memory formation states that memory traces reside on the network of cells activated during initial acquisition that becomes active again upon retrieval (reactivation). These activation and reactivation processes have been called “conjunctive trace.” This process implies that singular molecular events must occur during acquisition, strengthening the connection between the implicated cells whose synchronous activity must underlie subsequent reactivations. The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein. The expressions of these genes are reliably induced by behaviorally relevant neuronal activity and their products often play a central role in long-term memory formation. In this review, we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior, together with its versatile and central functions in synaptic plasticity could explain how familiarization and recognition memories are stored and preserved in the mammalian brain. |
| format | Article |
| id | doaj-art-e151e20af8b44e90a8cc98fed25e3c14 |
| institution | DOAJ |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e151e20af8b44e90a8cc98fed25e3c142025-08-20T03:21:06ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/184083184083New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from ArcJean-Pascal Morin0Kioko Guzmán-Ramos1Federico Bermudez-Rattoni2Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, Col. Juriquilla, 76230 Santiago de Querétaro, QRO, MexicoInstituto de Fisiología Celular, UNAM, Ciudad Universitaria, 04510 México, DF, MexicoInstituto de Fisiología Celular, UNAM, Ciudad Universitaria, 04510 México, DF, MexicoThe mainstream view on the neurobiological mechanisms underlying memory formation states that memory traces reside on the network of cells activated during initial acquisition that becomes active again upon retrieval (reactivation). These activation and reactivation processes have been called “conjunctive trace.” This process implies that singular molecular events must occur during acquisition, strengthening the connection between the implicated cells whose synchronous activity must underlie subsequent reactivations. The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein. The expressions of these genes are reliably induced by behaviorally relevant neuronal activity and their products often play a central role in long-term memory formation. In this review, we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior, together with its versatile and central functions in synaptic plasticity could explain how familiarization and recognition memories are stored and preserved in the mammalian brain.http://dx.doi.org/10.1155/2015/184083 |
| spellingShingle | Jean-Pascal Morin Kioko Guzmán-Ramos Federico Bermudez-Rattoni New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc Neural Plasticity |
| title | New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc |
| title_full | New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc |
| title_fullStr | New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc |
| title_full_unstemmed | New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc |
| title_short | New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc |
| title_sort | new insights on retrieval induced and ongoing memory consolidation lessons from arc |
| url | http://dx.doi.org/10.1155/2015/184083 |
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