Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis
ABSTRACT Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (P = 0.0186) and K-wires, respectivel...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2025-06-01
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| Series: | Microbiology Spectrum |
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| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.02372-24 |
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| author | Sebastian C. Herren Melissa J. Karau Christina Koscianski Kerryl E. Greenwood-Quaintance Jayawant N. Mandrekar Wen Wang Robin Patel |
| author_facet | Sebastian C. Herren Melissa J. Karau Christina Koscianski Kerryl E. Greenwood-Quaintance Jayawant N. Mandrekar Wen Wang Robin Patel |
| author_sort | Sebastian C. Herren |
| collection | DOAJ |
| description | ABSTRACT Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (P = 0.0186) and K-wires, respectively, of contezolid-treated compared to untreated rats. No MRSA was recovered from animals receiving rifampin alone or in combination with contezolid or vancomycin. There was no emergence of resistance to contezolid, vancomycin, or rifampin. |
| format | Article |
| id | doaj-art-e14ec62c378f4d4c884d3719205b666a |
| institution | DOAJ |
| issn | 2165-0497 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj-art-e14ec62c378f4d4c884d3719205b666a2025-08-20T03:07:32ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972025-06-0113610.1128/spectrum.02372-24Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitisSebastian C. Herren0Melissa J. Karau1Christina Koscianski2Kerryl E. Greenwood-Quaintance3Jayawant N. Mandrekar4Wen Wang5Robin Patel6Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USADivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USADivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USADivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USADepartment of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USADepartment of Biology, MicuRx Pharmaceuticals Inc., Shanghai, ChinaDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USAABSTRACT Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (P = 0.0186) and K-wires, respectively, of contezolid-treated compared to untreated rats. No MRSA was recovered from animals receiving rifampin alone or in combination with contezolid or vancomycin. There was no emergence of resistance to contezolid, vancomycin, or rifampin.https://journals.asm.org/doi/10.1128/spectrum.02372-24Methicillin-resistant Staphylococcus aureus (MRSA)osteomyelitiscontezolidvancomycinrifampinrat |
| spellingShingle | Sebastian C. Herren Melissa J. Karau Christina Koscianski Kerryl E. Greenwood-Quaintance Jayawant N. Mandrekar Wen Wang Robin Patel Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis Microbiology Spectrum Methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis contezolid vancomycin rifampin rat |
| title | Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis |
| title_full | Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis |
| title_fullStr | Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis |
| title_full_unstemmed | Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis |
| title_short | Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis |
| title_sort | activity of contezolid against methicillin resistant staphylococcus aureus in a rat model of foreign body osteomyelitis |
| topic | Methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis contezolid vancomycin rifampin rat |
| url | https://journals.asm.org/doi/10.1128/spectrum.02372-24 |
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