Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD
ObjectiveAdolescents with major depressive disorder (MDD) exhibit abnormal dynamic functional connectivity (dFC) patterns, but it remains unclear whether these aberrant dFC patterns are linked to antidepressant treatment. The aim of this study is to investigate whether dFC patterns will be changed b...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1487754/full |
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| author | Maojia Ran Hang Zhang Meijiang Jin Yuanmei Tao Hanmei Xu Shoukang Zou Zhujun Wang Fang Deng Lijuan Huang Hong Zhang Xiaowei Tang Yanping Wang Xia Fu Li Yin Li Yin Li Yin |
| author_facet | Maojia Ran Hang Zhang Meijiang Jin Yuanmei Tao Hanmei Xu Shoukang Zou Zhujun Wang Fang Deng Lijuan Huang Hong Zhang Xiaowei Tang Yanping Wang Xia Fu Li Yin Li Yin Li Yin |
| author_sort | Maojia Ran |
| collection | DOAJ |
| description | ObjectiveAdolescents with major depressive disorder (MDD) exhibit abnormal dynamic functional connectivity (dFC) patterns, but it remains unclear whether these aberrant dFC patterns are linked to antidepressant treatment. The aim of this study is to investigate whether dFC patterns will be changed by antidepressant treatment, as well as whether baseline dFC pattern could predict treatment response in adolescent MDD patients.MethodWe included 35 drug-naïve, first-episode MDD adolescents (age 14.40 ± 1.24; 8 males and 27 females) and 24 healthy controls (HCs, age 14.21 ± 1.41; 11 males and 13 females). All MDD adolescents received 6 weeks of antidepressant treatment. Resting state and T1 MRI data were collected in MDD adolescents before and after treatment and in HCs. Independent component analysis (ICA) was used to compare the different dFC pattern between MDD adolescents and HCs at baseline, as well as which between before and after treatment in MDD adolescents. Finally, Pearson correlation and multivariate linear regression analyses were used to explore the associations between dFC pattern and changed score of BDI in MDD adolescents.ResultsThe mean dFC value between right inferior frontal gyrus (IFG) and bilateral insular cortex (IC; right, r = −0.461, p-FDR = 0.012; left, r = −0.518, p-FDR = 0.007) at baseline were negatively correlated with BDI score reduction. The mean dFC value between left frontal pole (FP) and right superior parietal lobule (SPL) after treatment was positively correlated with BDI score reduction (r = 0.442, p-FDR = 0.014). And the mean dFC values between right IFG and bilateral IC (right, β = −1.563, p-FDR = 0.021; left, β = −1.868, p-FDR = 0.012) at baseline could predict antidepressant treatment response.ConclusionThese findings demonstrate that dFC patterns between some brain areas could be a prospective factor for predicting antidepressant treatment response. |
| format | Article |
| id | doaj-art-e14ca630f4a44ef68703d2fb0c84c117 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-e14ca630f4a44ef68703d2fb0c84c1172025-02-03T06:33:36ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.14877541487754Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDDMaojia Ran0Hang Zhang1Meijiang Jin2Yuanmei Tao3Hanmei Xu4Shoukang Zou5Zhujun Wang6Fang Deng7Lijuan Huang8Hong Zhang9Xiaowei Tang10Yanping Wang11Xia Fu12Li Yin13Li Yin14Li Yin15Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaFrontier Science Center for Disease-related Molecular Networks, Chengdu, Sichuan, ChinaSichuan Clinical Medical Research Center for Mental Disorders, Chengdu, Sichuan, ChinaObjectiveAdolescents with major depressive disorder (MDD) exhibit abnormal dynamic functional connectivity (dFC) patterns, but it remains unclear whether these aberrant dFC patterns are linked to antidepressant treatment. The aim of this study is to investigate whether dFC patterns will be changed by antidepressant treatment, as well as whether baseline dFC pattern could predict treatment response in adolescent MDD patients.MethodWe included 35 drug-naïve, first-episode MDD adolescents (age 14.40 ± 1.24; 8 males and 27 females) and 24 healthy controls (HCs, age 14.21 ± 1.41; 11 males and 13 females). All MDD adolescents received 6 weeks of antidepressant treatment. Resting state and T1 MRI data were collected in MDD adolescents before and after treatment and in HCs. Independent component analysis (ICA) was used to compare the different dFC pattern between MDD adolescents and HCs at baseline, as well as which between before and after treatment in MDD adolescents. Finally, Pearson correlation and multivariate linear regression analyses were used to explore the associations between dFC pattern and changed score of BDI in MDD adolescents.ResultsThe mean dFC value between right inferior frontal gyrus (IFG) and bilateral insular cortex (IC; right, r = −0.461, p-FDR = 0.012; left, r = −0.518, p-FDR = 0.007) at baseline were negatively correlated with BDI score reduction. The mean dFC value between left frontal pole (FP) and right superior parietal lobule (SPL) after treatment was positively correlated with BDI score reduction (r = 0.442, p-FDR = 0.014). And the mean dFC values between right IFG and bilateral IC (right, β = −1.563, p-FDR = 0.021; left, β = −1.868, p-FDR = 0.012) at baseline could predict antidepressant treatment response.ConclusionThese findings demonstrate that dFC patterns between some brain areas could be a prospective factor for predicting antidepressant treatment response.https://www.frontiersin.org/articles/10.3389/fnins.2025.1487754/fulladolescentMDDDfcantidepressanttreatment responseMRI |
| spellingShingle | Maojia Ran Hang Zhang Meijiang Jin Yuanmei Tao Hanmei Xu Shoukang Zou Zhujun Wang Fang Deng Lijuan Huang Hong Zhang Xiaowei Tang Yanping Wang Xia Fu Li Yin Li Yin Li Yin Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD Frontiers in Neuroscience adolescent MDD Dfc antidepressant treatment response MRI |
| title | Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD |
| title_full | Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD |
| title_fullStr | Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD |
| title_full_unstemmed | Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD |
| title_short | Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD |
| title_sort | dynamic functional connectivity patterns predict early antidepressant treatment response in drug naive first episode adolescent mdd |
| topic | adolescent MDD Dfc antidepressant treatment response MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1487754/full |
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