Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture

Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture

Multi-target analgesics with minimal side effects and high efficacy are a key research focus in addressing the global pain crisis. Using a molecular networking approach, five pairs of potent analgesic alkaloid enantiomers were isolated from the roots of Anacyclus pyrethrum (A. pyrethrum). Their stru...

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Bibliographic Details
Main Authors: Hui Chen, Hanqi Zhang, Chao Niu, Bianlin Wang, Biao Gao, Zhijun Liu, Guangmin Yao, Haji Akber Aisa
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Anacyclus pyrethrum
Asteraceae
Alkaloids
Analgesics
Multi-target analgesics
Ion channel blocker
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002990
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