Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.)
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l‐threonine produced by fermentation with Escherichia coli CGMCC 7.455 when used as a nutritional additive in feed and water for dri...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-04-01
|
| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2024.8708 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849427598506983424 |
|---|---|
| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Boet Glandorf Montserrat Anguita Matteo Lorenzo Innocenti Jordi Tarrés‐Call Elisa Pettenati |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Boet Glandorf Montserrat Anguita Matteo Lorenzo Innocenti Jordi Tarrés‐Call Elisa Pettenati |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l‐threonine produced by fermentation with Escherichia coli CGMCC 7.455 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain is genetically modified. None of the introduced genetic modifications raised a safety concern. Viable cells of the production strain and its DNA were not detected in the final additive. Therefore, the final product does not give raise to any safety concern regarding the genetic modification of the production strain. The use of l‐threonine (≥ 98.5%) produced with E. coli CGMCC 7.455 to supplement feed is safe for the target species. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) has concerns on the safety of the simultaneous oral administration of l‐threonine via water for drinking and feed due to possible amino acid imbalances and hygienic reasons. The use of l‐threonine produced with E. coli CGMCC 7.455 in animal nutrition raises no safety concerns to consumers of animal products and to the environment. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive to be irritant to skin or eyes, or on its potential to be a dermal sensitiser. The endotoxin activity in the additive does not pose a risk for the user via inhalation. The additive l‐threonine is regarded as an effective source of the amino acid l‐threonine for all non‐ruminant species. In order to be as efficacious in ruminants as in non‐ruminants, it should be protected from ruminal degradation. |
| format | Article |
| id | doaj-art-e14bd2042ccb4b738f70d6a53ef97ab7 |
| institution | Kabale University |
| issn | 1831-4732 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-e14bd2042ccb4b738f70d6a53ef97ab72025-08-20T03:28:58ZengWileyEFSA Journal1831-47322024-04-01224n/an/a10.2903/j.efsa.2024.8708Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenMojca DurjavaBirgit DusemundMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosRoberto Edoardo VillaRuud WoutersenBoet GlandorfMontserrat AnguitaMatteo Lorenzo InnocentiJordi Tarrés‐CallElisa PettenatiAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l‐threonine produced by fermentation with Escherichia coli CGMCC 7.455 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain is genetically modified. None of the introduced genetic modifications raised a safety concern. Viable cells of the production strain and its DNA were not detected in the final additive. Therefore, the final product does not give raise to any safety concern regarding the genetic modification of the production strain. The use of l‐threonine (≥ 98.5%) produced with E. coli CGMCC 7.455 to supplement feed is safe for the target species. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) has concerns on the safety of the simultaneous oral administration of l‐threonine via water for drinking and feed due to possible amino acid imbalances and hygienic reasons. The use of l‐threonine produced with E. coli CGMCC 7.455 in animal nutrition raises no safety concerns to consumers of animal products and to the environment. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive to be irritant to skin or eyes, or on its potential to be a dermal sensitiser. The endotoxin activity in the additive does not pose a risk for the user via inhalation. The additive l‐threonine is regarded as an effective source of the amino acid l‐threonine for all non‐ruminant species. In order to be as efficacious in ruminants as in non‐ruminants, it should be protected from ruminal degradation.https://doi.org/10.2903/j.efsa.2024.8708amino acidefficacyEscherichia coli CGMCC 7.455l‐threoninenutritional additivesafety |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Boet Glandorf Montserrat Anguita Matteo Lorenzo Innocenti Jordi Tarrés‐Call Elisa Pettenati Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.) EFSA Journal amino acid efficacy Escherichia coli CGMCC 7.455 l‐threonine nutritional additive safety |
| title | Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.) |
| title_full | Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.) |
| title_fullStr | Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.) |
| title_full_unstemmed | Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.) |
| title_short | Safety and efficacy of a feed additive consisting of l‐threonine (produced with Escherichia coli CGMCC 7.455) for all animal species (Kempex Holland B.V.) |
| title_sort | safety and efficacy of a feed additive consisting of l threonine produced with escherichia coli cgmcc 7 455 for all animal species kempex holland b v |
| topic | amino acid efficacy Escherichia coli CGMCC 7.455 l‐threonine nutritional additive safety |
| url | https://doi.org/10.2903/j.efsa.2024.8708 |
| work_keys_str_mv | AT efsapanelonadditivesandproductsorsubstancesusedinanimalfeedfeedap safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT vasileiosbampidis safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT giovannaazimonti safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT mariadelourdesbastos safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT henrikchristensen safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT mojcadurjava safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT birgitdusemund safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT marylinekouba safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT martalopezalonso safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT secundinolopezpuente safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT francescamarcon safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT baltasarmayo safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT alenapechova safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT marianapetkova safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT fernandoramos safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT robertoedoardovilla safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT ruudwoutersen safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT boetglandorf safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT montserratanguita safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT matteolorenzoinnocenti safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT jorditarrescall safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv AT elisapettenati safetyandefficacyofafeedadditiveconsistingoflthreonineproducedwithescherichiacolicgmcc7455forallanimalspecieskempexhollandbv |