Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer
Ovarian cancer ranks as Indonesia’s third-leading cause of cancer-related death, emphasising the need for innovative treatments. This study combined bioinformatics, molecular docking, and experimental assays to tackle this challenge. We identified 166 ovarian cancer-related genes, with MYC standing...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Toxicology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666027X25000167 |
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| author | Retno Murwanti Ritmaleni Navista Sri Octa Ujiantari I Made Rhamandana Putra Aliffian Farhan Wahyudi Vigha Ilmanafi Arifka |
| author_facet | Retno Murwanti Ritmaleni Navista Sri Octa Ujiantari I Made Rhamandana Putra Aliffian Farhan Wahyudi Vigha Ilmanafi Arifka |
| author_sort | Retno Murwanti |
| collection | DOAJ |
| description | Ovarian cancer ranks as Indonesia’s third-leading cause of cancer-related death, emphasising the need for innovative treatments. This study combined bioinformatics, molecular docking, and experimental assays to tackle this challenge. We identified 166 ovarian cancer-related genes, with MYC standing out as a key target. Analysis of MYC mutations revealed prevalent alterations, though no significant survival differences were observed in patients with or without the mutations. Molecular docking pinpointed compound B155 as a promising MYC inhibitor. A preliminary cytotoxicity assay revealed compound B155′s notable activity, with an 87.19 % inhibition of cell viability at 50 μM. Most of the other curcumin analogues only caused more than 50 % inhibition at the same concentration. This result suggests alternative mechanisms of action, possibly antioxidant effects, warranting further exploration. In summary, this study unveiled MYC as a prime target for ovarian cancer treatment, with curcumin analogues like B155 showing potential. Nonetheless, the complex factors affecting cytotoxicity underscore the need for deeper investigation into these compounds’ mechanisms in ovarian cancer cells. |
| format | Article |
| id | doaj-art-e14b5db720e64176ab5759b92e602a3d |
| institution | OA Journals |
| issn | 2666-027X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Toxicology |
| spelling | doaj-art-e14b5db720e64176ab5759b92e602a3d2025-08-20T02:03:14ZengElsevierCurrent Research in Toxicology2666-027X2025-01-01810023010.1016/j.crtox.2025.100230Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancerRetno Murwanti0 Ritmaleni1Navista Sri Octa Ujiantari2I Made Rhamandana Putra3Aliffian Farhan Wahyudi4Vigha Ilmanafi Arifka5Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Corresponding author at: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaOvarian cancer ranks as Indonesia’s third-leading cause of cancer-related death, emphasising the need for innovative treatments. This study combined bioinformatics, molecular docking, and experimental assays to tackle this challenge. We identified 166 ovarian cancer-related genes, with MYC standing out as a key target. Analysis of MYC mutations revealed prevalent alterations, though no significant survival differences were observed in patients with or without the mutations. Molecular docking pinpointed compound B155 as a promising MYC inhibitor. A preliminary cytotoxicity assay revealed compound B155′s notable activity, with an 87.19 % inhibition of cell viability at 50 μM. Most of the other curcumin analogues only caused more than 50 % inhibition at the same concentration. This result suggests alternative mechanisms of action, possibly antioxidant effects, warranting further exploration. In summary, this study unveiled MYC as a prime target for ovarian cancer treatment, with curcumin analogues like B155 showing potential. Nonetheless, the complex factors affecting cytotoxicity underscore the need for deeper investigation into these compounds’ mechanisms in ovarian cancer cells.http://www.sciencedirect.com/science/article/pii/S2666027X25000167Ovarian cancerCurcumin analoguesDibenzylidene-cyclopentanoneCytotoxicityBioinformatics |
| spellingShingle | Retno Murwanti Ritmaleni Navista Sri Octa Ujiantari I Made Rhamandana Putra Aliffian Farhan Wahyudi Vigha Ilmanafi Arifka Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer Current Research in Toxicology Ovarian cancer Curcumin analogues Dibenzylidene-cyclopentanone Cytotoxicity Bioinformatics |
| title | Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer |
| title_full | Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer |
| title_fullStr | Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer |
| title_full_unstemmed | Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer |
| title_short | Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer |
| title_sort | bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer |
| topic | Ovarian cancer Curcumin analogues Dibenzylidene-cyclopentanone Cytotoxicity Bioinformatics |
| url | http://www.sciencedirect.com/science/article/pii/S2666027X25000167 |
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