Review on inhibition mechanism of tea polyphenols against tumor immune escape
Tea polyphenols (TP) are the main active compounds in tea leaves. It is found that TP could inhibit cancer cell growth and induce cell apoptosis via modulating cell cycle, gene expression, signal transduction and transcription factor, etc. However, due to the low bioavailability of TP, it is hard fo...
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| Format: | Article |
| Language: | English |
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Zhejiang University Press
2018-09-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
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| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2018.05.021 |
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| _version_ | 1850070201858523136 |
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| author | KONG Dedong ZHAO Yueling WANG Yuefei XU Ping |
| author_facet | KONG Dedong ZHAO Yueling WANG Yuefei XU Ping |
| author_sort | KONG Dedong |
| collection | DOAJ |
| description | Tea polyphenols (TP) are the main active compounds in tea leaves. It is found that TP could inhibit cancer cell growth and induce cell apoptosis via modulating cell cycle, gene expression, signal transduction and transcription factor, etc. However, due to the low bioavailability of TP, it is hard for TP to work on cancer cells directly, which leading to the anti-tumor mechanism effect of TP is still unclear. As known, tumor immune escape is found to play a key role in tumor genesis and growth; immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), are able to regulate anti-tumor immune response negatively, and mainly contribute to tumor immune escape. Recently, TP have been found to relieve immune escape and suppress spontaneous neuroblastoma cells through MDSCs, which provide a new sight into understanding the anti-tumor effect of TP. In this paper, the recent researches on the effects of tea polyphenols on immunosuppressive cells were reviewed in order to provide a reference for studying the anti-tumor mechanisms of tea polyphenols. |
| format | Article |
| id | doaj-art-e148f7b9553c4b36a051a04495b958fe |
| institution | DOAJ |
| issn | 1008-9209 2097-5155 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | 浙江大学学报. 农业与生命科学版 |
| spelling | doaj-art-e148f7b9553c4b36a051a04495b958fe2025-08-20T02:47:36ZengZhejiang University Press浙江大学学报. 农业与生命科学版1008-92092097-51552018-09-014453954810.3785/j.issn.1008-9209.2018.05.02110089209Review on inhibition mechanism of tea polyphenols against tumor immune escapeKONG DedongZHAO YuelingWANG YuefeiXU PingTea polyphenols (TP) are the main active compounds in tea leaves. It is found that TP could inhibit cancer cell growth and induce cell apoptosis via modulating cell cycle, gene expression, signal transduction and transcription factor, etc. However, due to the low bioavailability of TP, it is hard for TP to work on cancer cells directly, which leading to the anti-tumor mechanism effect of TP is still unclear. As known, tumor immune escape is found to play a key role in tumor genesis and growth; immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), are able to regulate anti-tumor immune response negatively, and mainly contribute to tumor immune escape. Recently, TP have been found to relieve immune escape and suppress spontaneous neuroblastoma cells through MDSCs, which provide a new sight into understanding the anti-tumor effect of TP. In this paper, the recent researches on the effects of tea polyphenols on immunosuppressive cells were reviewed in order to provide a reference for studying the anti-tumor mechanisms of tea polyphenols.https://www.academax.com/doi/10.3785/j.issn.1008-9209.2018.05.021tea polyphenolsimmune escapemyeloid-derived suppressor cellsanti-tumor |
| spellingShingle | KONG Dedong ZHAO Yueling WANG Yuefei XU Ping Review on inhibition mechanism of tea polyphenols against tumor immune escape 浙江大学学报. 农业与生命科学版 tea polyphenols immune escape myeloid-derived suppressor cells anti-tumor |
| title | Review on inhibition mechanism of tea polyphenols against tumor immune escape |
| title_full | Review on inhibition mechanism of tea polyphenols against tumor immune escape |
| title_fullStr | Review on inhibition mechanism of tea polyphenols against tumor immune escape |
| title_full_unstemmed | Review on inhibition mechanism of tea polyphenols against tumor immune escape |
| title_short | Review on inhibition mechanism of tea polyphenols against tumor immune escape |
| title_sort | review on inhibition mechanism of tea polyphenols against tumor immune escape |
| topic | tea polyphenols immune escape myeloid-derived suppressor cells anti-tumor |
| url | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2018.05.021 |
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