Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus
The aim of this research was to determine larvicidal activity of the ethanol extract of Inula racemosa Hook. f. (Compositae) roots against the larvae of the Culicidae mosquito Aedes albopictus and to isolate any larvicidal constituents from the extract. Based on bioactivity-guided fractionation, 11,...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/738796 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562505345400832 |
|---|---|
| author | Qing He Xin Chao Liu Rui Qi Sun Zhi Wei Deng Shu Shan Du Zhi Long Liu |
| author_facet | Qing He Xin Chao Liu Rui Qi Sun Zhi Wei Deng Shu Shan Du Zhi Long Liu |
| author_sort | Qing He |
| collection | DOAJ |
| description | The aim of this research was to determine larvicidal activity of the ethanol extract of Inula racemosa Hook. f. (Compositae) roots against the larvae of the Culicidae mosquito Aedes albopictus and to isolate any larvicidal constituents from the extract. Based on bioactivity-guided fractionation, 11,13-dihydroisoalantolactone (1), macrophyllilactone E (2), 5α-epoxyalantolactone (3), and epoxyisoalantolactone (4) were isolated and identified as the active constituents. Compounds 1 and 2 exhibited strong larvicidal activity against the early fourth-instar larvae of A. albopictus with LC50 values of 21.86 μg/mL and 18.65 μg/mL, respectively, while the ethanol extract had a LC50 value of 25.23 μg/mL. Compounds 3 and 4 also possessed larvicidal activity against the Asian tiger mosquitoes with LC50 values of 29.37 μg/mL and 35.13 μg/mL, respectively. The results indicated that the ethanol extract of I. racemosa and the four isolated constituents have potential for use in the control of A. albopictus larvae and could be useful in the search of newer, safer, and more effective natural compounds as larvicides. |
| format | Article |
| id | doaj-art-e144d3a0f6174e158cea387257bfa258 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e144d3a0f6174e158cea387257bfa2582025-02-03T01:22:36ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/738796738796Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictusQing He0Xin Chao Liu1Rui Qi Sun2Zhi Wei Deng3Shu Shan Du4Zhi Long Liu5State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, ChinaDepartment of Entomology, China Agricultural University, 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaAnalytical and Testing Center, Beijing Normal University, Beijing 100875, ChinaAnalytical and Testing Center, Beijing Normal University, Beijing 100875, ChinaState Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, ChinaDepartment of Entomology, China Agricultural University, 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaThe aim of this research was to determine larvicidal activity of the ethanol extract of Inula racemosa Hook. f. (Compositae) roots against the larvae of the Culicidae mosquito Aedes albopictus and to isolate any larvicidal constituents from the extract. Based on bioactivity-guided fractionation, 11,13-dihydroisoalantolactone (1), macrophyllilactone E (2), 5α-epoxyalantolactone (3), and epoxyisoalantolactone (4) were isolated and identified as the active constituents. Compounds 1 and 2 exhibited strong larvicidal activity against the early fourth-instar larvae of A. albopictus with LC50 values of 21.86 μg/mL and 18.65 μg/mL, respectively, while the ethanol extract had a LC50 value of 25.23 μg/mL. Compounds 3 and 4 also possessed larvicidal activity against the Asian tiger mosquitoes with LC50 values of 29.37 μg/mL and 35.13 μg/mL, respectively. The results indicated that the ethanol extract of I. racemosa and the four isolated constituents have potential for use in the control of A. albopictus larvae and could be useful in the search of newer, safer, and more effective natural compounds as larvicides.http://dx.doi.org/10.1155/2014/738796 |
| spellingShingle | Qing He Xin Chao Liu Rui Qi Sun Zhi Wei Deng Shu Shan Du Zhi Long Liu Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus Journal of Chemistry |
| title | Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus |
| title_full | Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus |
| title_fullStr | Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus |
| title_full_unstemmed | Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus |
| title_short | Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus |
| title_sort | mosquito larvicidal constituents from the ethanol extract of inula racemosa hook f roots against aedes albopictus |
| url | http://dx.doi.org/10.1155/2014/738796 |
| work_keys_str_mv | AT qinghe mosquitolarvicidalconstituentsfromtheethanolextractofinularacemosahookfrootsagainstaedesalbopictus AT xinchaoliu mosquitolarvicidalconstituentsfromtheethanolextractofinularacemosahookfrootsagainstaedesalbopictus AT ruiqisun mosquitolarvicidalconstituentsfromtheethanolextractofinularacemosahookfrootsagainstaedesalbopictus AT zhiweideng mosquitolarvicidalconstituentsfromtheethanolextractofinularacemosahookfrootsagainstaedesalbopictus AT shushandu mosquitolarvicidalconstituentsfromtheethanolextractofinularacemosahookfrootsagainstaedesalbopictus AT zhilongliu mosquitolarvicidalconstituentsfromtheethanolextractofinularacemosahookfrootsagainstaedesalbopictus |