Small molecule modulation of p75NTR engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease

Small molecule modulation of p75NTR engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene encoding a mutant huntingtin (mHtt) protein. mHtt aggregates within neurons causing degeneration primarily in the striatum. There is currently a need for disease-modifying treatments for H...

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Bibliographic Details
Main Authors: Danielle A. Simmons, Namitha Alexander, Gloria Cao, Ido Rippin, Yarine Lugassy, Hagit Eldar-Finkelman, Frank M. Longo
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
Subjects:
Neurotrophin
Huntingtin inclusions
Neurodegeneration
Autophagy
p75NTR
Online Access:http://www.sciencedirect.com/science/article/pii/S187874792400182X
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